Emergence of azole-resistant aspergillus fumigatus strains due to agricultural azole use creates an increasing threat to human health

  [...]50% of the patients with invasive aspergillosis due to ARAF are known to be azole naïve and the outcome of patients with azole-resistant invasive aspergillosis has been dismal, with a mortality rate of 88% [12]. [...]it would be beneficial to (i) have an active multi-azole susceptibility tes...

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Bibliographic Details
Published in:PLoS pathogens 2013-10, Vol.9 (10), p.e1003633
Main Authors: Chowdhary, Anuradha, Kathuria, Shallu, Xu, Jianping, Meis, Jacques F
Format: Article
Language:English
Subjects:
Agriculture
Aspergillosis
Aspergillus
Aspergillus fumigatus - metabolism
Azoles - pharmacology
Composting
Drug Resistance, Fungal - drug effects
Fungi
Fungicides, Industrial - pharmacology
Genes
Health aspects
Health promotion
Host-parasite relationships
Humans
Management
Mortality
Mutation
Pearls
Pesticides
Physiological aspects
Public health
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Summary:  [...]50% of the patients with invasive aspergillosis due to ARAF are known to be azole naïve and the outcome of patients with azole-resistant invasive aspergillosis has been dismal, with a mortality rate of 88% [12]. [...]it would be beneficial to (i) have an active multi-azole susceptibility testing of A. fumigatus to monitor the extent of the problem, (ii) reduce agricultural use of triazole DMI fungicides, and (iii) use combination drug therapy when dealing with infections by A. fumigatus strains to limit the emergence of resistance.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1003633