Functional IL-23R rs10889677 genetic polymorphism and risk of multiple solid tumors: a meta-analysis

Interleukin-23 receptor (IL23R) can interact with IL-23 and, thus, is involved in the T-helper 17 (Th17) cell-mediated inflammatory process as well as tumorigenesis. Recently, a functional single nucleotide polymorphism (SNP) rs10889677 has been identified in the 3'-untranslated region of IL-23...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2013-11, Vol.8 (11), p.e80627-e80627
Main Authors: Zhou, Shanliang, Ruan, Yueqin, Yu, Hongchen, Chen, Yunzhi, Yao, Yongjun, Ma, Yanhui, Gao, Yan
Format: Article
Language:English
Subjects:
3' Untranslated Regions
Bias
Binding sites
Breast cancer
Case-Control Studies
Confidence intervals
Cytokines
Cytotoxicity
Development and progression
Disease susceptibility
Gastric cancer
Gene polymorphism
Genetic aspects
Genetic diversity
Genetic transformation
Genetic variance
Head & neck cancer
Health risk assessment
Helper cells
Hospitals
Humans
Inflammation
Interleukin 23
Interleukins
Laboratories
Lung cancer
Lymphocytes T
Medical ethics
Meta-analysis
miRNA
Neoplasms - genetics
Oral cancer
Ovarian cancer
Pancreatic cancer
Polymorphism
Polymorphism, Single Nucleotide
Receptors, Interleukin - genetics
Ribonucleic acid
RNA
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Solid tumors
Stomach cancer
Studies
Transformation
Tumorigenesis
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Interleukin-23 receptor (IL23R) can interact with IL-23 and, thus, is involved in the T-helper 17 (Th17) cell-mediated inflammatory process as well as tumorigenesis. Recently, a functional single nucleotide polymorphism (SNP) rs10889677 has been identified in the 3'-untranslated region of IL-23R. It has been showed that the rs10889677AC SNP could increase the binding affinity of microRNA let-7f and downregulate IL-23R expression. Several case-control studies have examined the association between this SNP and genetic susceptibility of multiple solid tumors. However, the conclusions are conflicting. Therefore, we conducted this meta-analysis to systematically study the role of this functional IL-23R SNP in development of multiple solid tumors. There are a total of 5 studies are eligible (6731 cases and 7296 healthy controls). Either fixed-effect model or random-effect model was used to calculate pooled odds ratios (ORs) and the 95% confidence interval (95% CI). Significant association between this functional rs10889677 genetic variant and risk of multiple solid tumors were observed (CC genotype vs. AA genotype: OR = 0.59, 95% CI = 0.53-0.66, P < 0.001). These findings demonstrated that the IL-23R rs10889677 genetic variant might play an important part during malignant transformation of multiple solid tumors.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0080627