Elevated procoagulant endothelial and tissue factor expressing microparticles in women with recurrent pregnancy loss

15% of reproducing couples suffer from pregnancy loss(PL) and recurs in 2-3%. One of the most frequently hypothesized causes of unexplained PL refers to a defective maternal haemostatic response leading to uteroplacental thrombosis. Hereditary thrombophilia and antiphospholipid antibodies have been...

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Bibliographic Details
Published in:PloS one 2013-11, Vol.8 (11), p.e81407-e81407
Main Authors: Patil, Rucha, Ghosh, Kanjaksha, Satoskar, Purnima, Shetty, Shrimati
Format: Article
Language:English
Subjects:
Abortion
Abortion, Habitual - blood
Abortion, Habitual - immunology
Abortion, Habitual - metabolism
Adult
Antibodies
Antibodies, Antiphospholipid
Anticoagulants
Antigens
Antiphospholipid antibodies
Biological effects
Biomarkers - blood
Blood Coagulation Tests
Blood platelets
Case-Control Studies
CD45 antigen
Cell-Derived Microparticles - metabolism
Cloning
Clotting
Confidence intervals
Defects
Endothelium
Erythrocytes
Female
Flow cytometry
Humans
Immunoglobulins
Leukocytes
Markers
Medical research
Microparticles
Miscarriage
Pathogenesis
Phosphatidylserine
Plasma
Platelets
Political aspects
Preeclampsia
Pregnancy
Pregnant women
Risk analysis
Risk factors
Standardization
Thromboembolism
Thrombophilia
Thrombophilia - blood
Thrombophilia - metabolism
Thrombosis
Tissue factor
Ultrasonic imaging
Women's health
Womens health
Young Adult
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Summary:15% of reproducing couples suffer from pregnancy loss(PL) and recurs in 2-3%. One of the most frequently hypothesized causes of unexplained PL refers to a defective maternal haemostatic response leading to uteroplacental thrombosis. Hereditary thrombophilia and antiphospholipid antibodies have been extensively described as risk factors for PL in women with unknown aetiology. Recently, a new marker has emerged: the cell-derived procoagulant circulating microparticles(MPs) which have been reported to have a major role in many thrombosis complicated diseases. This study aims to analyze the significance of procoagulant MPs in women suffering from unexplained recurrent pregnancy loss(RPL), and characterize their cellular origin. 115 women with RPL were analyzed for common thrombophilia markers and different cell derived MPs-total annexinV, platelet(CD41a), endothelial(CD146,CD62e), leukocyte(CD45), erythrocyte(CD235a) and tissue factor(CD142)(TF) expressing MPs and were compared with 20 healthy non-pregnant women. Methodology for MP analysis was standardized by participating in the "Vascular Biology Scientific and Standardization Committee workshop". Total annexinV, TF and endothelial MPs were found significantly increased(p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0081407