An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia

Recent genetic analyses have implicated several candidate susceptibility variants for schizophrenia. The single nucleotide polymorphism (SNP) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cogniti...

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Published in:PloS one 2013-11, Vol.8 (11), p.e80696-e80696
Main Authors: Liu, Jiewei, Numata, Shusuke, Ikeda, Masashi, Watanabe, Yuichiro, Zheng, Xue-Bin, Luo, Xiongjian, Kinoshita, Makoto, Nunokawa, Ayako, Someya, Toshiyuki, Ohmori, Tetsuro, Bei, Jin-Xin, Chong, Siow-Ann, Lee, Jimmy, Li, Zhiqiang, Liu, Jianjun, Iwata, Nakao, Shi, Yongyong, Li, Ming, Su, Bing
Format: Article
Language:English
Subjects:
Adult
Age
Asian Continental Ancestry Group - genetics
Association analysis
Behavior disorders
Cardiomyopathy
Case-Control Studies
Cognitive ability
Disease susceptibility
Drug abuse
Genes
Genetic aspects
Genetic Association Studies
Genetic Predisposition to Disease
Genetics
Genomes
Health informatics
Hippocampus
Hippocampus - pathology
Humans
Laboratories
Mental disorders
Mental health
Meta-analysis
NMR
Nuclear magnetic resonance
Patients
Polymorphism
Polymorphism, Single Nucleotide - genetics
Population
Populations
Principal components analysis
Psychiatry
Replication
Schizophrenia
Schizophrenia - genetics
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Studies
University graduates
Zoology
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Summary:Recent genetic analyses have implicated several candidate susceptibility variants for schizophrenia. The single nucleotide polymorphism (SNP) rs7294919 is likely a schizophrenia-susceptibility variant according to its significant association with hippocampal volume, hippocampus function, and cognitive performance as well as the nominal association with schizophrenia. However, all previous analyses were conducted only in Europeans, and whether rs7294919 is associated with schizophrenia in other populations are yet to be tested. Here, we conducted a case-control analysis of rs7294919 with schizophrenia in six independent Chinese (N = 3) and Japanese (N = 3) samples, including a total of 7,352 cases and 10,824 controls. The results of our association analysis were not able to confirm the association of rs7294919 with schizophrenia (p = 0.51 in total samples, odds ratio = 1.02 for allele[C]). The absence of rs7294919's association in Chinese and Japanese suggest a potential genetic heterogeneity in the susceptibility of schizophrenia on this locus and also demonstrate the difficulties in replicating associations of schizophrenia across different ethnic populations.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0080696