Serum uric acid is associated with left ventricular hypertrophy independent of serum parathyroid hormone in male cardiac patients

Several studies have shown that serum uric acid (UA) is associated with left ventricular (LV) hypertrophy. Serum levels of parathyroid hormone (PTH), which has bbe shown to be correlated with UA, is also known to be associated with cardiac hypertrophy; however, whether the association between UA and...

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Published in:PloS one 2013-12, Vol.8 (12), p.e82735-e82735
Main Authors: Fujita, Shu-ichi, Okamoto, Yusuke, Shibata, Kensaku, Morita, Hideaki, Ito, Takahide, Sohmiya, Koichi, Hoshiga, Masaaki, Ishizaka, Nobukazu
Format: Article
Language:English
Subjects:
Acids
Aged
Biomarkers - blood
Body mass
Body mass index
Body size
Calcium
Calcium metabolism
Calcium phosphates
Cardiac patients
Cardiology
Confidence intervals
Correlation
Diabetes
Diuretics
Diuretics - administration & dosage
Drugs
Geometry
Heart
Heart diseases
Heart hypertrophy
Humans
Hypertension
Hypertrophy
Hypertrophy, Left Ventricular - blood
Hypertrophy, Left Ventricular - drug therapy
Laboratories
Male
Metabolism
Middle Aged
Parathyroid
Parathyroid hormone
Parathyroid Hormone - blood
Parathyroid hormones
Patients
Phosphates
Physiological aspects
Population
Regression analysis
Retrospective Studies
Rodents
Serum levels
Statistical analysis
Studies
Uric acid
Uric Acid - blood
Ventricle
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Summary:Several studies have shown that serum uric acid (UA) is associated with left ventricular (LV) hypertrophy. Serum levels of parathyroid hormone (PTH), which has bbe shown to be correlated with UA, is also known to be associated with cardiac hypertrophy; however, whether the association between UA and cardiac hypertrophy is independent of PTH remains unknown. We investigated whether the relationship between serum uric acid (UA) and LV hypertrophy is independent of intact PTH and other calcium-phosphate metabolism-related factors in cardiac patients. In a retrospective study, the association between UA and left ventricular mass index was assessed among 116 male cardiac patients (mean age 65 ± 12 years) who were not taking UA lowering drugs. The median UA value was 5.9 mg/dL. Neither age nor body mass index differed significantly among the UA quartile groups. Patients with higher UA levels were more likely to be taking loop diuretics. UA showed a significant correlation with intact PTH (R = 0.34, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0082735