Influence of APOE genotype on whole-brain functional networks in cognitively normal elderly

This study aimed to investigate the influence of apolipoprotein E (APOE) ε4 allele on whole-brain functional networks in cognitively normal (CN) elderly by applying graph theoretical analysis to brain glucose metabolism. Eighty-six CN elderly [28 APOE ε4 carriers (ε4+) and 58 non-carriers (ε4-)] und...

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Bibliographic Details
Published in:PloS one 2013-12, Vol.8 (12), p.e83205-e83205
Main Authors: Seo, Eun Hyun, Lee, Dong Young, Lee, Jong-Min, Park, Jun-Sung, Sohn, Bo Kyung, Choe, Young Min, Byun, Min Soo, Choi, Hyo Jung, Woo, Jong Inn
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging - genetics
Alzheimer Disease - diagnostic imaging
Alzheimer Disease - genetics
Alzheimer's disease
Apolipoprotein E
Apolipoproteins
Apolipoproteins E - genetics
Biomedical engineering
Brain
Brain research
Carriers
Clustering
Cognition
Cognitive ability
Consortia
Dementia
Disease susceptibility
Elderly
Emission analysis
Family medical history
Female
Genetic aspects
Genotype
Geriatrics
Glucose
Glucose metabolism
Health risk assessment
Hippocampus - diagnostic imaging
Hospitals
Humans
Interdisciplinary aspects
Male
Medicine
Memory
Metabolism
Middle Aged
Nerve Net - diagnostic imaging
Networks
Neural networks
NMR
Nuclear magnetic resonance
Older people
Physiological aspects
Positron emission
Positron emission tomography
Radiography
Studies
Theoretical analysis
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Summary:This study aimed to investigate the influence of apolipoprotein E (APOE) ε4 allele on whole-brain functional networks in cognitively normal (CN) elderly by applying graph theoretical analysis to brain glucose metabolism. Eighty-six CN elderly [28 APOE ε4 carriers (ε4+) and 58 non-carriers (ε4-)] underwent clinical evaluation and resting [(18)F] fluorodeoxyglucose positron emission tomography scan. Whole-brain functional networks were constructed from correlations of the 90 regions of interest using the automated anatomical labeling template, and analyzed using graph theoretical approaches. The overall small-world property seen in ε4- was preserved in ε4+. However, both local clustering and path length were lower in ε4+ compared to ε4-. In terms of the hubs of functional networks, ε4+ showed decreased centrality of the right hippocampus but increased centrality of several brain regions associated with the default mode network compared to ε4-. Our results indicate that genetic vulnerability to Alzheimer's disease may alter whole-brain functional networks even before clinical symptoms appear.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0083205