DNA methylation of IGF2DMR and H19 is associated with fetal and infant growth: the generation R study

Changes in epigenetic programming of embryonic growth genes during pregnancy seem to affect fetal growth. Therefore, in a population-based prospective birth cohort in the Netherlands, we examined associations between fetal and infant growth and DNA methylation of IGF2DMR, H19 and MTHFR. For this stu...

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Bibliographic Details
Published in:PloS one 2013-12, Vol.8 (12), p.e81731-e81731
Main Authors: Bouwland-Both, Marieke I, van Mil, Nina H, Stolk, Lisette, Eilers, Paul H C, Verbiest, Michael M P J, Heijmans, Bastiaan T, Tiemeier, Henning, Hofman, Albert, Steegers, Eric A P, Jaddoe, Vincent W V, Steegers-Theunissen, Régine P M
Format: Article
Language:English
Subjects:
Adult
Analysis
Attention deficit hyperactivity disorder
Birth weight
Blood cells
Case-Control Studies
Child development
Childbirth & labor
Children
Deoxyribonucleic acid
Dependent variables
DNA
DNA Methylation
Embryos
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Female
Fetal development
Fetus
Fetuses
Gene Expression Regulation, Developmental
Genes
Genetic diversity
Genetic variance
Genomic Imprinting
Gestational age
Growth
Health risk assessment
Humans
Infant, Newborn
Infant, Small for Gestational Age - growth & development
Infant, Small for Gestational Age - metabolism
Infants
Insulin-like growth factor II
Insulin-Like Growth Factor II - genetics
Insulin-Like Growth Factor II - metabolism
Leukocytes
Mediation
Medical records
Medical research
Methylation
Methylenetetrahydrofolate reductase
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Methylenetetrahydrofolate Reductase (NADPH2) - metabolism
Pregnancy
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Small for gestational age
Ultrasound
Umbilical cord
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Summary:Changes in epigenetic programming of embryonic growth genes during pregnancy seem to affect fetal growth. Therefore, in a population-based prospective birth cohort in the Netherlands, we examined associations between fetal and infant growth and DNA methylation of IGF2DMR, H19 and MTHFR. For this study, we selected 69 case children born small-for-gestational age (SGA, birth weight
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0081731