The fly muscles in on glycogen autophagy

  [...]the authors found that an enzyme called glycogen phosphorylase operates independently of the autophagy pathway to break down glycogen in starving larval muscle. By introducing various mutations into GlyS, the researchers showed that this interaction only takes place during starvation and that...

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Bibliographic Details
Published in:PLoS biology 2013-11, Vol.11 (11), p.e1001709-e1001709
Main Author: Sedwick, Caitlin
Format: Article
Language:English
Subjects:
Animals
Autophagy
Autophagy (Cytology)
Enzymes
Glycogen
Glycogen - metabolism
Muscular Diseases - metabolism
Muscular system
Physiological aspects
Proteins
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Summary:  [...]the authors found that an enzyme called glycogen phosphorylase operates independently of the autophagy pathway to break down glycogen in starving larval muscle. By introducing various mutations into GlyS, the researchers showed that this interaction only takes place during starvation and that it is enhanced when GlyS is enzymatically active. [...]during starvation, GlyS may simultaneously bind to both Atg8 and glycogen, thereby bringing glycogen to the autophagosome.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.1001709