Exome sequencing identifies early gastric carcinoma as an early stage of advanced gastric cancer

Gastric carcinoma is one of the major causes of cancer-related mortality worldwide. Early detection and treatment leads to an excellent prognosis in patients with early gastric cancer (EGC), whereas the prognosis of patients with advanced gastric cancer (AGC) remains poor. It is unclear whether EGCs...

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Bibliographic Details
Published in:PloS one 2013-12, Vol.8 (12), p.e82770
Main Authors: Kang, Guhyun, Hwang, Woo Cheol, Do, In-Gu, Wang, Kai, Kang, So Young, Lee, Jeeyun, Park, Se Hoon, Park, Joon Oh, Kang, Won Ki, Jang, Jiryeon, Choi, Min-Gew, Lee, Jun Ho, Sohn, Tae Sung, Bae, Jae Moon, Kim, Sung, Kim, Min Ji, Kim, Seonwoo, Park, Cheol Keun, Kim, Kyoung-Mee
Format: Article
Language:English
Subjects:
Aged
Biomedical research
Cancer
Carcinogenesis
Carcinogens
Carcinoma
Care and treatment
Cell adhesion & migration
Deoxyribonucleic acid
Development and progression
DNA
DNA methylation
Early Detection of Cancer - methods
Exome - genetics
Female
Gastric cancer
Gastroenterology
Gene expression
Gene frequency
Genes
Genetic aspects
Genomes
Health aspects
Hematology
Humans
Intestine
Male
Medical prognosis
Medicine
Microsatellite Instability
Middle Aged
Mortality
Mutation
Mutation - genetics
Neoplasm Staging
Oncology
Pathology
Patients
Physicians
Prognosis
Sequence Analysis, DNA - methods
Stomach cancer
Stomach Neoplasms - diagnosis
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
Surgery
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Summary:Gastric carcinoma is one of the major causes of cancer-related mortality worldwide. Early detection and treatment leads to an excellent prognosis in patients with early gastric cancer (EGC), whereas the prognosis of patients with advanced gastric cancer (AGC) remains poor. It is unclear whether EGCs and AGCs are distinct entities or whether EGCs are the beginning stages of AGCs. We performed whole exome sequencing of four samples from patients with EGC and compared the results with those from AGCs. In both EGCs and AGCs, a total of 268 genes were commonly mutated and independent mutations were additionally found in EGCs (516 genes) and AGCs (3104 genes). A higher frequency of C>G transitions was observed in intestinal-type compared to diffuse-type carcinomas (P = 0.010). The DYRK3, GPR116, MCM10, PCDH17, PCDHB1, RDH5 and UNC5C genes are recurrently mutated in EGCs and may be involved in early carcinogenesis.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0082770