Reproductive and exogenous hormone factors in relation to risk of meningioma in women: a meta-analysis

A number of studies have focused on the association between oral contraceptive (OC), hormonal replacement therapy (HRT) and reproductive factors and meningioma risk, but the results were inconsistent. Thus, a meta-analysis was performed to obtain more precise estimates of risk. We conducted a litera...

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Bibliographic Details
Published in:PloS one 2013-12, Vol.8 (12), p.e83261
Main Authors: Qi, Zhen-Yu, Shao, Chuan, Huang, Yu-Lun, Hui, Guo-Zhen, Zhou, You-Xin, Wang, Zhong
Format: Article
Language:English
Subjects:
Age
Age Factors
Brain cancer
Case-Control Studies
Cohort Studies
Estrogens
Female
Health risk assessment
Hormone replacement therapy
Hormone Replacement Therapy - adverse effects
Hormones
Humans
Ionizing radiation
Medicine
Menarche
Meningioma
Meningioma - etiology
Meningioma - metabolism
Menopause
Meta-analysis
Oral contraceptives
Parity
Post-menopause
Postmenopausal women
Postmenopause
Risk Assessment
Risk Factors
Sex hormones
Studies
Time Factors
Women
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Summary:A number of studies have focused on the association between oral contraceptive (OC), hormonal replacement therapy (HRT) and reproductive factors and meningioma risk, but the results were inconsistent. Thus, a meta-analysis was performed to obtain more precise estimates of risk. We conducted a literature search using PubMed and EMBASE databases to July 2013, without any limitations. Random effects models were used to summarize results. Twelve case-control and six cohort studies were included in this meta-analysis. We found that an increased risk of meningioma was associated with HRT use(RR = 1.19, 95% CI = 1.01-1.40), postmenopausal women(RR = 1.32, 95% CI = 1.07-1.64) and parity(RR = 1.18, 95% CI = 1.00-1.40).No significant associations were observed for OC use (RR = 0.93, 95% CI = 0.83-1.03), age at menarche(RR = 1.06, 95% CI = 0.92-1.21), age at menopause(RR = 1.03, 95% CI = 0.81-1.30), or age at first birth(RR = 0.94, 95% CI = 0.80-1.10). In conclusion, the results of our study support the hypothesis that longer exposure to effect of female sex hormones may increase the risk of meningioma in women, yet additional studies are warranted to confirm our findings and identify the underlying biological mechanisms.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0083261