Prevalence of and factors associated with albuminuria in the Korean adult population: the 2011 Korea National Health and Nutrition Examination Survey

• Published in: PloS one 2013-12, Vol.8 (12), p.e83273-e83273
• Main Authors: Won, Jong Chul, Lee, Yun Jeong, Kim, Jung Min, Han, Sang Youb, Noh, Jung Hyun, Ko, Kyung Soo, Rhee, Byoung Doo, Kim, Dong-Jun
• Format: Article
• Language: English
• Subjects: Adult; Age; Age Factors; Albuminuria - epidemiology; Albuminuria - etiology; Alcohol; Aspartate; Aspartate aminotransferase; Biology; Blood pressure; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Creatinine; Diabetes; Diabetes mellitus; Disease control; Family medical history; Female; Glomerular filtration rate; Health risks; Health surveys; Hospitals; Humans; Hypertension; Insulin resistance; Internal medicine; Kidney diseases; Kidney transplantation; Male; Medical research; Medicine; Metabolic disorders; Middle Aged; Nutrition; Nutrition Surveys; Obesity; Population; Population studies; Prevalence; Prevalence studies (Epidemiology); Regression analysis; Republic of Korea; Risk analysis; Risk Factors; Rodents; Sex; Surveys; Urine; Waist Circumference
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0083273

Microalbuminuria is associated with increased risk of renal disease and cardiovascular diseases even in non-diabetic subjects. High incidence rates of microalbuminuria have been found in a number of population-based studies. However, the prevalence and risk factors associated with microalbuminuria in the general population in Korea are unclear. The present study was performed to estimate the prevalence of microalbuminuria and investigate the associated risk factors in the general adult population using the Fifth Korea National Health and Nutrition Examination Survey (KNHANES V-2) data from 2011. A total of 5,202 participants (mean age, 45.6 years; men, 2,337; women, 2,865) were included in the analysis. Microalbuminuria was evaluated in participants of KNHANES V-2 based on the urine albumin-creatinine ratio. Estimated glomerular filtration rate was calculated using the Modification of Diet in Renal Disease study equation. The weighted prevalence of microalbuminuria was 5.2% (95% CI, 4.4-6.1) in the general population. The prevalence of albuminuria is increased with age. After adjustment for age and sex, the presence of albuminuria was associated with increased waist circumference, systolic and diastolic blood pressure, aspartate aminotransferase, triglyceride, fasting plasma glucose, and the presence of hypertension and diabetes. In logistic regression analyses, older age, female sex, diabetes, hypertension, and serum aspartate aminotransferase were independently associated with the presence of albuminuria. The prevalence of microalbuminuria was found to be 5.2%, and conventional risk factors for cardiovascular diseases are closely related to the presence of microalbuminuria in Korea. Microalbuminuria may be a useful marker to identify individuals with increased risk of cardiovascular disease.