The contribution of diet and genotype to iron status in women: a classical twin study

This is the first published report examining the combined effect of diet and genotype on body iron content using a classical twin study design. The aim of this study was to determine the relative contribution of genetic and environmental factors in determining iron status. The population was compris...

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Bibliographic Details
Published in:PloS one 2013-12, Vol.8 (12), p.e83047-e83047
Main Authors: Fairweather-Tait, Susan J, Guile, Geoffrey R, Valdes, Ana M, Wawer, Anna A, Hurst, Rachel, Skinner, Jane, Macgregor, Alexander J
Format: Article
Language:English
Subjects:
Adult
Analysis
Biology
Body mass
Body mass index
Calcium
Calcium, Dietary - administration & dosage
Chromosomes
Cytochrome b Group - genetics
Diet
Environmental factors
Female
Ferritin
Ferritins - blood
Food
Genes
Genetic aspects
Genetic Markers
Genotype
Hemochromatosis Protein
Heritability
Histocompatibility Antigens Class I - genetics
Humans
Iron
Iron - metabolism
Iron content
Iron deficiency anemia
Medical schools
Medicine
Membrane Proteins - genetics
Menstruation
Middle Aged
Nutrition research
Oxidoreductases - genetics
Polymorphism, Single Nucleotide
Receptors, Transferrin - blood
Receptors, Transferrin - genetics
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Solubility
Transferrin
Transferrin - genetics
Transferrins
Twin studies
Twins
Twins, Dizygotic
Twins, Monozygotic
Variance analysis
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Summary:This is the first published report examining the combined effect of diet and genotype on body iron content using a classical twin study design. The aim of this study was to determine the relative contribution of genetic and environmental factors in determining iron status. The population was comprised of 200 BMI- and age-matched pairs of MZ and DZ healthy twins, characterised for habitual diet and 15 iron-related candidate genetic markers. Variance components analysis demonstrated that the heritability of serum ferritin (SF) and soluble transferrin receptor was 44% and 54% respectively. Measured single nucleotide polymorphisms explained 5% and selected dietary factors 6% of the variance in iron status; there was a negative association between calcium intake and body iron (p = 0.02) and SF (p = 0.04).
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0083047