Thoracoscopic lobectomy versus open lobectomy in stage I non-small cell lung cancer: a meta-analysis

The objective of the present meta-analysis was to evaluate the survival, recurrence rate, and complications in patients with stage I non-small cell lung cancer (NSCLC) who received video-assisted thoracoscopic surgery (VATS) or open lobectomy. A literature search was conducted on June 31, 2012 using...

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Bibliographic Details
Published in:PloS one 2013-12, Vol.8 (12), p.e82366-e82366
Main Authors: Cai, Yi-xin, Fu, Xiang-ning, Xu, Qin-zi, Sun, Wei, Zhang, Ni
Format: Article
Language:English
Subjects:
Air leakage
Cancer
Cancer surgery
Cancer treatment
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - surgery
Care and treatment
Cell survival
Chemotherapy
Comparative analysis
Complications
Confidence intervals
Criteria
Cytokines
Hospitals
Humans
Lobectomy
Lung cancer
Lung diseases
Lung Neoplasms - mortality
Lung Neoplasms - surgery
Lymphatic system
Medical prognosis
Medicine
Meta-analysis
Neoplasm Recurrence, Local
Non-small cell lung cancer
Non-small cell lung carcinoma
Ostomy
Patients
Pneumonectomy - adverse effects
Pneumonectomy - methods
Pneumonectomy - mortality
Pneumonia
Prospective Studies
Retrospective Studies
Science
Small cell lung cancer
Small cell lung carcinoma
Statistical analysis
Studies
Surgery
Survival
Survival Rate
Thoracic surgery
Thoracic Surgery, Video-Assisted - adverse effects
Thoracic Surgery, Video-Assisted - methods
Thoracic Surgery, Video-Assisted - mortality
Thorax
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Summary:The objective of the present meta-analysis was to evaluate the survival, recurrence rate, and complications in patients with stage I non-small cell lung cancer (NSCLC) who received video-assisted thoracoscopic surgery (VATS) or open lobectomy. A literature search was conducted on June 31, 2012 using combinations of the search terms video-assisted thoracic surgery, open thoracotomy, lobectomy, and non-small-cell lung cancer (NSCLC). Inclusion criteria were: 1) Compared video-assisted thoracic surgery (VATS) lobectomy with open lobectomy. 2) Stage I NSCLC. 2) No previous treatment for lung cancer. 4) Outcome data included 5-year survival rate, complication, and recurrence rate. Tests of heterogeneity, sensitivity, and publication bias were performed. A total of 23 studies (21 retrospective and 2 prospective) met the inclusion criteria. VATS was associated with a longer 5-year survival (odds ratio [OR] = 1.622, 95% confidence interval [CI] 1.272 to 2.069; P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0082366