Perinatal outcomes by mode of assisted conception and sub-fertility in an Australian data linkage cohort

Fertility treatment is associated with increased risk of major birth defects, which varies between in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), and is significantly reduced by embryo freezing. We therefore examined a range of additional perinatal outcomes for these expos...

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Bibliographic Details
Published in:PloS one 2014-01, Vol.9 (1), p.e80398-e80398
Main Authors: Marino, Jennifer L, Moore, Vivienne M, Willson, Kristyn J, Rumbold, Alice, Whitrow, Melissa J, Giles, Lynne C, Davies, Michael J
Format: Article
Language:English
Subjects:
Adult
Australia - epidemiology
Biology
Birth defects
Birth weight
Childbirth & labor
Confidence intervals
Congenital defects
Data Collection
Death
Embryos
Female
Fertility
Fertilization
Fertilization in Vitro - statistics & numerical data
Freezing
Gestation
Gestational age
Humans
In vitro fertilization
Infant mortality
Infertility
Infertility, Female - epidemiology
Live Birth - epidemiology
Low birth weight
Male
Medicine
Mortality
Neonates
Newborn babies
Newborn infants
Patient outcomes
Pregnancy
Pregnancy Outcome - epidemiology
Premature birth
Reproductive Techniques, Assisted - statistics & numerical data
Reproductive technologies
Risk
Stillbirth - epidemiology
Systematic review
Twins - statistics & numerical data
Womens health
Young Adult
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Summary:Fertility treatment is associated with increased risk of major birth defects, which varies between in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), and is significantly reduced by embryo freezing. We therefore examined a range of additional perinatal outcomes for these exposures. All patients in South Australia receiving assisted conception between Jan 1986-Dec 2002 were linked to the state-wide perinatal collection (all births/stillbirths ≥20 weeks gestation or 400 g birth weight, n = 306 995). We examined stillbirth, mean birth weight, low birth weight (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0080398