The reversed feto-maternal bile acid gradient in intrahepatic cholestasis of pregnancy is corrected by ursodeoxycholic acid

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder associated with an increased risk of adverse fetal outcomes. It is characterised by raised maternal serum bile acids, which are believed to cause the adverse outcomes. ICP is commonly treated with ursodeoxycholic acid...

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Bibliographic Details
Published in:PloS one 2014-01, Vol.9 (1), p.e83828-e83828
Main Authors: Geenes, Victoria, Lövgren-Sandblom, Anita, Benthin, Lisbet, Lawrance, Dominic, Chambers, Jenny, Gurung, Vinita, Thornton, Jim, Chappell, Lucy, Khan, Erum, Dixon, Peter, Marschall, Hanns-Ulrich, Williamson, Catherine
Format: Article
Language:English
Subjects:
Acids
Bile
Bile acids
Bile Acids and Salts - blood
Biology
Case-Control Studies
Chenodeoxycholic acid
Cholestasis
Cholestasis, Intrahepatic - blood
Cholestasis, Intrahepatic - drug therapy
Chromatography, High Pressure Liquid
Compartments
Deoxycholic acid
diagnosis
expression
Female
fetal
Glycine - blood
High performance liquid chromatography
human placenta
Humans
Liquid chromatography
Liver
Liver diseases
Mass Spectrometry
maternal liver tandem
Maternal-Fetal Exchange
Medicin och hälsovetenskap
Medicine
metabolism
oatp-c
obstetric cholestasis
Obstetrics, Gynecology and Reproductive Medicine
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - drug therapy
Pregnant women
profiles
Reproduktionsmedicin och gynekologi
salt
Taurine - blood
transport
Umbilical Arteries - metabolism
Umbilical cord
Umbilical Veins - metabolism
Ursodeoxycholic acid
Ursodeoxycholic Acid - therapeutic use
Ursodiol
Womens health
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Summary:Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder associated with an increased risk of adverse fetal outcomes. It is characterised by raised maternal serum bile acids, which are believed to cause the adverse outcomes. ICP is commonly treated with ursodeoxycholic acid (UDCA). This study aimed to determine the fetal and maternal bile acid profiles in normal and ICP pregnancies, and to examine the effect of UDCA treatment. Matched maternal and umbilical cord serum samples were collected from untreated ICP (n = 18), UDCA-treated ICP (n = 46) and uncomplicated pregnancy (n = 15) cases at the time of delivery. Nineteen individual bile acids were measured using HPLC-MS/MS. Maternal and fetal serum bile acids are significantly raised in ICP compared with normal pregnancy (p = 
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0083828