Combined impact of cardiorespiratory fitness and visceral adiposity on metabolic syndrome in overweight and obese adults in Korea

• Published in: PloS one 2014-01, Vol.9 (1), p.e85742-e85742
• Main Authors: Kim, Sue, Kim, Ji-Young, Lee, Duk-Chul, Lee, Hye-Sun, Lee, Ji-Won, Jeon, Justin Y
• Format: Article
• Language: English
• Subjects: Adipose tissue; Adiposity; Adult; Adults; Analysis; Body weight; Cardiorespiratory fitness; Cardiovascular diseases; Confidence intervals; Exercise; Exercise tests; Female; Health aspects; Heart rate; Humans; Insulin resistance; Intra-Abdominal Fat - pathology; Male; Medicine; Metabolic syndrome; Metabolic Syndrome - etiology; Metabolic Syndrome - pathology; Metabolic Syndrome - physiopathology; Middle Aged; Mortality; Obesity; Obesity - complications; Obesity - pathology; Obesity - physiopathology; Overweight; Physical Fitness; Republic of Korea; Young Adult
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0085742

Obesity, especially visceral obesity, is known to be an important correlate for cardiovascular disease and increased mortality. On the other hand, high cardiorespiratory fitness is suggested to be an effective contributor for reducing this risk. This study was conducted to determine the combined impact of cardiorespiratory fitness and visceral adiposity, otherwise known as fitness and fatness, on metabolic syndrome in overweight and obese adults. A total of 232 overweight and obese individuals were grouped into four subtypes according to their fitness level. This was measured by recovery heart rate from a step test in addition to visceral adiposity defined as the visceral adipose tissue area to subcutaneous adipose tissue area ratio (VAT/SAT ratio). Associations of fitness and visceral fatness were analyzed in comparison with the prevalence of metabolic syndrome. The high visceral fat and low fitness group had the highest prevalence of metabolic syndrome [Odds Ratio (OR) 5.02; 95% Confidence Interval (CI) 1.85-13.61] compared with the reference group, which was the low visceral adiposity and high fitness group, after adjustments for confounding factors. Viscerally lean but unfit subjects were associated with a higher prevalence of metabolic syndrome than more viscerally obese but fit subjects (OR 3.42; 95% CI 1.27-9.19, and OR 2.70; 95% CI 1.01-7.25, respectively). Our study shows that visceral obesity and fitness levels are cumulatively associated with a higher prevalence of metabolic syndrome in healthy overweight and obese adults. This suggests that cardiorespiratory fitness is a significant modifier in the relation of visceral adiposity to adverse metabolic outcomes in overweight and obese individuals.