Zinc sequestration: arming phagocyte defense against fungal attack

  [...]the struggle for Zn2+ between host and pathogen impacts survival of the invader and defense by the immune system. A role for heavy metal efflux pumps in fungal resistance to metal poisoning remains to be dissected. [...]the immune system utilizes divergent Zn2+ restriction or intoxication mec...

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Bibliographic Details
Published in:PLoS pathogens 2013-12, Vol.9 (12), p.e1003815-e1003815
Main Authors: Subramanian Vignesh, Kavitha, Landero Figueroa, Julio A, Porollo, Aleksey, Caruso, Joseph A, Deepe, Jr, George S
Format: Article
Language:English
Subjects:
Animals
Binding sites
Cell division
Fungi
Fungi - immunology
Fungi - metabolism
Fungi, Pathogenic
Health aspects
Homeostasis
Host-parasite relationships
Host-Pathogen Interactions - immunology
Humans
Immune system
Immunity, Cellular
Metals
Microbiological research
Mycoses - immunology
Mycoses - metabolism
Nutritional Physiological Phenomena
Pearls
Phagocytes
Phagocytes - immunology
Phagocytes - metabolism
Physiological aspects
Poisoning
Proteins
Zinc
Zinc - metabolism
Zinc in the body
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Summary:  [...]the struggle for Zn2+ between host and pathogen impacts survival of the invader and defense by the immune system. A role for heavy metal efflux pumps in fungal resistance to metal poisoning remains to be dissected. [...]the immune system utilizes divergent Zn2+ restriction or intoxication mechanisms to combat infection. Collectively, Zn2+ restriction drives antifungal defense through a concurrent twofold effect: first, it induces Zn2+ starvation in the pathogen, and second, it strengthens oxidative burst-mediated defenses of the innate system. [...]innate immunity is equipped with a variety of Zn2+ restriction strategies that function cooperatively to eliminate pathogens.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1003815