Coronaviruses as DNA wannabes: a new model for the regulation of RNA virus replication fidelity

  Much beyond this rate, RNA viruses risk crossing an "error threshold," or the point at which there are too many deleterious mutations for the viral population to reproduce faithfully [4]. [...]while allowing for enormous population diversity, the low-fidelity of RdRp-mediated replication...

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Bibliographic Details
Published in:PLoS pathogens 2013-12, Vol.9 (12), p.e1003760-e1003760
Main Authors: Smith, Everett Clinton, Denison, Mark R
Format: Article
Language:English
Subjects:
Animals
Coronavirus - genetics
Coronaviruses
Deoxyribonucleic acid
DNA
DNA, Viral
E coli
Editing
Genetic aspects
Genetic research
Genome, Viral
Genomes
Health aspects
Humans
Models, Genetic
Mutation
Pearls
Physiological aspects
Population
Proteins
RNA sequencing
RNA Viruses - genetics
RNA, Viral - genetics
RNA-Dependent RNA Polymerase - physiology
Virus Replication - genetics
Viruses
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Summary:  Much beyond this rate, RNA viruses risk crossing an "error threshold," or the point at which there are too many deleterious mutations for the viral population to reproduce faithfully [4]. [...]while allowing for enormous population diversity, the low-fidelity of RdRp-mediated replication imposes constraints on both viral genome size and maintenance of genomic integrity, theoretically limiting the size of RNA virus genomes to around ~15 kb (reviewed in [4]). [...]the probability that fidelity is regulated by a multi-protein complex involving nsp12-RdRp, nsp14-ExoN, and nsp10 suggests that interference with fidelity could be achieved through the disruption of multiple enzymatic activities and/or protein-protein interactions.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1003760