Association between kidney function and Framingham global cardiovascular disease risk score: a Chinese longitudinal study

Chronic kidney disease (CKD) is generally considered an independent risk factor for cardiovascular disease (CVD) development, but rates in individuals with estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m(2) are uncertain. The Framingham global CVD risk score (FRS) equation is a wide...

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Published in:PloS one 2014-01, Vol.9 (1), p.e86082-e86082
Main Authors: Jin, Bo, Bai, Xiaojuan, Han, Lulu, Liu, Jing, Zhang, Weiguang, Chen, Xiangmei
Format: Article
Language:English
Subjects:
Adult
Aged
Biology
Blood pressure
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
China - epidemiology
Chronic kidney failure
Collaboration
Correlation analysis
Correlation coefficient
Correlation coefficients
Diabetes
Epidemiology
Epidermal growth factor receptors
Female
Glomerular Filtration Rate
Health risk assessment
Health risks
Humans
Kidney diseases
Longitudinal Studies
Male
Medical research
Medicine
Middle Aged
Physics
Renal function
Renal Insufficiency, Chronic - complications
Risk analysis
Risk Factors
Risk groups
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Summary:Chronic kidney disease (CKD) is generally considered an independent risk factor for cardiovascular disease (CVD) development, but rates in individuals with estimated glomerular filtration rate (eGFR) >60 ml/min/1.73 m(2) are uncertain. The Framingham global CVD risk score (FRS) equation is a widely accepted tool used to predict CVD risk in the general population. The purpose of the present study was to examine whether an association exists between eGFR and FRS in a Chinese population with no CKD or CVD. A total of 333 participants were divided into three groups based on FRS. The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and CKD-EPI equation for Asians (CKD-EPI-ASIA) were used to measure eGFR. A significant inverse association between eGFR and FRS was confirmed with Pearson correlation coefficients of -0.669, -0.698 (eGFR(CKD-EPI), P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0086082