Platelet turnover in stable coronary artery disease - influence of thrombopoietin and low-grade inflammation

• Published in: PloS one 2014-01, Vol.9 (1), p.e85566-e85566
• Main Authors: Larsen, Sanne Bøjet, Grove, Erik Lerkevang, Hvas, Anne-Mette, Kristensen, Steen Dalby
• Format: Article
• Language: English
• Subjects: Acute coronary syndromes; Age Factors; Aged; Atherosclerosis; Biology; Blood platelets; Blood Platelets - metabolism; Blood Platelets - pathology; C-Reactive Protein - metabolism; Cardiology; Cardiovascular disease; Coronary artery; Coronary artery disease; Coronary Artery Disease - blood; Coronary Artery Disease - complications; Coronary Artery Disease - pathology; Coronary vessels; Cross-Sectional Studies; Cytokines; Cytometry; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - pathology; Diabetics; Female; Flow cytometry; Health sciences; Heart attack; Heart attacks; Heart diseases; Hematology; Humans; Inflammation; Inflammation - blood; Inflammation - complications; Inflammation - pathology; Interleukin 6; Interleukin-6 - blood; Interleukins; Kidneys; Kinases; Male; Mean Platelet Volume; Medical law; Medical research; Medicine; Middle Aged; Myocardial infarction; Myocardial Infarction - blood; Myocardial Infarction - complications; Myocardial Infarction - pathology; Patients; Platelet Count; Platelets; Proteins; Quality; Renal insufficiency; Renal Insufficiency - blood; Renal Insufficiency - complications; Renal Insufficiency - pathology; Sex Factors; Smoking; Studies; Thrombopoietin; Thrombopoietin - blood; Type 2 diabetes
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0085566

Newly formed platelets are associated with increased aggregation and adverse outcomes in patients with coronary artery disease (CAD). The mechanisms involved in the regulation of platelet turnover in patients with CAD are largely unknown. To investigate associations between platelet turnover parameters, thrombopoietin and markers of low-grade inflammation in patients with stable CAD. Furthermore, to explore the relationship between platelet turnover parameters and type 2 diabetes, prior myocardial infarction, smoking, age, gender and renal insufficiency. We studied 581 stable CAD patients. Platelet turnover parameters (immature platelet fraction, immature platelet count, mean platelet volume, platelet distribution width and platelet large cell-ratio) were determined using automated flow cytometry (Sysmex XE-2100). Furthermore, we measured thrombopoietin and evaluated low-grade inflammation by measurement of high-sensitive CRP and interleukin-6. We found strong associations between the immature platelet fraction, immature platelet count, mean platelet volume, platelet distribution width and platelet large cell ratio (r = 0.61-0.99, p