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Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans

The regulation of energy balance involves an intricate interplay between neural mechanisms that respond to internal and external cues of energy demand and food availability. Compelling data have implicated the neurotransmitter dopamine as an important part of body weight regulation. However, the pre...

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Bibliographic Details
Published in:PloS one 2014, Vol.9 (1), p.e85874-e85874
Main Authors: Barros, Alexandre Guimarães de Almeida, Bridi, Jessika Cristina, de Souza, Bruno Rezende, de Castro Júnior, Célio, de Lima Torres, Karen Cecília, Malard, Leandro, Jorio, Ado, de Miranda, Débora Marques, Ashrafi, Kaveh, Romano-Silva, Marco Aurélio
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Language:English
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Summary:The regulation of energy balance involves an intricate interplay between neural mechanisms that respond to internal and external cues of energy demand and food availability. Compelling data have implicated the neurotransmitter dopamine as an important part of body weight regulation. However, the precise mechanisms through which dopamine regulates energy homeostasis remain poorly understood. Here, we investigate mechanisms through which dopamine modulates energy storage. We showed that dopamine signaling regulates fat reservoirs in Caenorhabditis elegans. We found that the fat reducing effects of dopamine were dependent on dopaminergic receptors and a set of fat oxidation enzymes. Our findings reveal an ancient role for dopaminergic regulation of fat and suggest that dopamine signaling elicits this outcome through cascades that ultimately mobilize peripheral fat depots.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0085874