Genetic instability persists in non-neoplastic urothelial cells from patients with a history of urothelial cell carcinoma

Bladder cancer is one of the most common genitourinary neoplasms in industrialized countries. Multifocality and high recurrence rates are prominent clinical features of this disease and contribute to its high morbidity. Therefore, more sensitive and less invasive techniques could help identify indiv...

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Bibliographic Details
Published in:PloS one 2014-01, Vol.9 (1), p.e86162-e86162
Main Authors: de Castro Marcondes, João Paulo, de Oliveira, Maria Luiza Cotrim Sartor, Gontijo, Alisson M, de Camargo, João Lauro Viana, Salvadori, Daisy Maria Fávero
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alcohol
Alcohol use
Alcoholic beverages
Antineoplastic agents
Biology
Biomarkers
Bladder
Bladder cancer
Carcinoma
Carcinoma - genetics
Carcinoma - pathology
Case-Control Studies
Cell division
Cellular biology
Chromosomes
Cytogenetics
Disease control
Disease prevention
DNA damage
Epithelial Cells - metabolism
Epithelial Cells - pathology
Female
Fluorescence
Fluorescence in situ hybridization
Gene amplification
Gene expression
Genomic Instability
Habits
Humans
Hybridization analysis
Invasiveness
Male
Males
Medical diagnosis
Medicine
Micronuclei
Micronuclei, Chromosome-Defective
Micronucleus Tests
Middle Aged
Monitoring
Morbidity
Mutation
Neoplasm Grading
Neoplasm Staging
Neoplasms
Patients
Pesticides
Regression analysis
Risk Factors
Smoking
Stability
Tumors
Urinary bladder
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - pathology
Urologic Neoplasms - genetics
Urologic Neoplasms - pathology
Urothelial cancer
Urothelium
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Summary:Bladder cancer is one of the most common genitourinary neoplasms in industrialized countries. Multifocality and high recurrence rates are prominent clinical features of this disease and contribute to its high morbidity. Therefore, more sensitive and less invasive techniques could help identify individuals with asymptomatic disease. In this context, we used the micronucleus assay to evaluate whether cytogenetic alterations could be used as biomarkers for monitoring patients with a history of urothelial cell carcinoma (UCC). We determined the frequency of micronucleated urothelial cells (MNC) in exfoliated bladder cells from 105 patients with (n = 52) or without (n = 53) a history of UCC, all of whom tested negative for neoplasia by cytopathological and histopathological analyses. MNC frequencies were increased in patients with a history of UCC (non-smoker and smoker/ex-smoker patients vs non-smoker and smoker/ex-smoker controls; p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0086162