Angiotensin-induced abdominal aortic aneurysms in hypercholesterolemic mice: role of serum cholesterol and temporal effects of exposure

Understanding variations in size and pattern of development of angiotensin II (Ang II)-induced abdominal aortic aneurysms (AAA) may inform translational research strategies. Thus, we sought insight into the temporal evolution of AAA in apolipoprotein (apo)E(-/-) mice. A cohort of mice underwent a 4-...

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Bibliographic Details
Published in:PloS one 2014-01, Vol.9 (1), p.e84517
Main Authors: Prins, Petra A, Hill, Michael F, Airey, David, Nwosu, Sam, Perati, Prudhvidhar R, Tavori, Hagai, F Linton, Macrae, Kon, Valentina, Fazio, Sergio, Sampson, Uchechukwu K
Format: Article
Language:English
Subjects:
Abdomen
Aneurysm
Aneurysms
Angiotensin
Angiotensin II
Angiotensins
Animal models
Animals
Aorta
Aortic Aneurysm, Abdominal - blood
Aortic Aneurysm, Abdominal - chemically induced
Aortic Aneurysm, Abdominal - diagnostic imaging
Aortic Aneurysm, Abdominal - immunology
Aortic aneurysms
Apolipoproteins
Apolipoproteins E - deficiency
Apolipoproteins E - genetics
Atherosclerosis - blood
Atherosclerosis - complications
Atherosclerosis - immunology
Biology
Biomarkers
Blood cholesterol
Cholesterol
Cholesterol - blood
Coronary vessels
Drug dosages
Elastin - metabolism
Exposure
Hemodynamics
Hypercholesterolemia
Hypercholesterolemia - blood
Hypercholesterolemia - complications
Hypercholesterolemia - immunology
Immunology
Inflammation
Infusion
Laboratories
Lipoproteins (low density)
Low density lipoprotein
Macrophages - immunology
Male
Mathematics
Matrix Metalloproteinase 2 - metabolism
Medical research
Medicine
Mice
Mice, Inbred C57BL
Muscle, Smooth, Vascular - enzymology
Oxidative stress
Pathology
Regression analysis
Regression models
Rodents
Smooth muscle
Statistical analysis
Time Factors
Ultrasonic imaging
Ultrasonography
Ultrasound
Ultrasound imaging
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Summary:Understanding variations in size and pattern of development of angiotensin II (Ang II)-induced abdominal aortic aneurysms (AAA) may inform translational research strategies. Thus, we sought insight into the temporal evolution of AAA in apolipoprotein (apo)E(-/-) mice. A cohort of mice underwent a 4-week pump-mediated infusion of saline (n = 23) or 1500 ng/kg/min of Ang II (n = 85) and AAA development was tracked via in vivo ultrasound imaging. We adjusted for hemodynamic covariates in the regression models for AAA occurrence in relation to time. The overall effect of time was statistically significant (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0084517