Chloroquine is grossly under dosed in young children with malaria: implications for drug resistance

Plasmodium falciparum malaria is treated with 25 mg/kg of chloroquine (CQ) irrespective of age. Theoretically, CQ should be dosed according to body surface area (BSA). The effect of dosing CQ according to BSA has not been determined but doubling the dose per kg doubled the efficacy of CQ in children...

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Bibliographic Details
Published in:PloS one 2014-01, Vol.9 (1), p.e86801
Main Authors: Ursing, Johan, Eksborg, Staffan, Rombo, Lars, Bergqvist, Yngve, Blessborn, Daniel, Rodrigues, Amabelia, Kofoed, Poul-Erik
Format: Article
Language:English
Subjects:
Adolescent
Africa
Age
Age Factors
Antimalarials - therapeutic use
Child
Child, Preschool
Children
Chloroquine
Chloroquine - therapeutic use
Clinical trials
Confidence intervals
Consent
Dosage
Dose-Response Relationship, Drug
Drug Administration Schedule
Drug dosages
Drug Resistance
Drug therapy
Effectiveness
Ethics
Female
Follow-Up Studies
Health and Welfare
Hospitals
Humans
Hälsa och välfärd
Laboratories
Liver
Malaria
Malaria, Falciparum - blood
Malaria, Falciparum - drug therapy
Malaria, Falciparum - parasitology
Male
Medical research
Medicin och hälsovetenskap
Medicine
Plasmodium falciparum
Plasmodium falciparum - isolation & purification
Review boards
Studies
Surface area
Treatment Outcome
Tropical diseases
Vector-borne diseases
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Description
Summary:Plasmodium falciparum malaria is treated with 25 mg/kg of chloroquine (CQ) irrespective of age. Theoretically, CQ should be dosed according to body surface area (BSA). The effect of dosing CQ according to BSA has not been determined but doubling the dose per kg doubled the efficacy of CQ in children aged
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0086801