Influence of ATP-binding cassette transporter 1 R219K and M883I polymorphisms on development of atherosclerosis: a meta-analysis of 58 studies

Numerous epidemiological studies have evaluated the associations between ATP-binding cassette transporter 1 (ABCA1) R219K (rs2230806) and M883I (rs4149313) polymorphisms and atherosclerosis (AS), but results remain controversial. The purpose of the present study is to investigate whether these two p...

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Published in:PloS one 2014-01, Vol.9 (1), p.e86480-e86480
Main Authors: Yin, Yan-Wei, Li, Jing-Cheng, Gao, Dong, Chen, Yan-Xiu, Li, Bing-Hu, Wang, Jing-Zhou, Liu, Yun, Liao, Shao-Qiong, Zhang, Ming-Jie, Gao, Chang-Yue, Zhang, Li-Li
Format: Article
Language:English
Subjects:
ABCA1 protein
Alleles
Arteriosclerosis
Atherosclerosis
Atherosclerosis - genetics
Atherosclerosis - pathology
ATP
ATP Binding Cassette Transporter 1 - genetics
ATP-binding protein
Biology
Cardiovascular disease
Case-Control Studies
Clinical trials
Cohort analysis
Epidemiology
Genetic aspects
Genetic Predisposition to Disease
Humans
Medical ethics
Medicine
Meta-analysis
Mutation
Polymorphism
Polymorphism, Genetic - genetics
Prognosis
Scientific papers
Search engines
Statistical analysis
Studies
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Summary:Numerous epidemiological studies have evaluated the associations between ATP-binding cassette transporter 1 (ABCA1) R219K (rs2230806) and M883I (rs4149313) polymorphisms and atherosclerosis (AS), but results remain controversial. The purpose of the present study is to investigate whether these two polymorphisms facilitate the susceptibility to AS using a meta-analysis. PubMed, Embase, Web of Science, Medline, Cochrane database, Clinicaltrials.gov, Current Controlled Trials, Chinese Clinical Trial Registry, CBMdisc, CNKI, Google Scholar and Baidu Library were searched to get the genetic association studies. All statistical analyses were done with Stata 11.0. Forty-seven articles involving 58 studies were included in the final meta-analysis. For the ABCA1 R219K polymorphism, 42 studies involving 12,551 AS cases and 19,548 controls were combined showing significant association between this variant and AS risk (for K allele vs. R allele: OR = 0.77, 95% CI = 0.71-0.84, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0086480