Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration

Fructose-bisphosphate aldolase A (ALDOA) is a key enzyme in glycolysis and is responsible for catalyzing the reversible conversion of fructose-1,6-bisphosphate to glyceraldehydes-3-phosphate and dihydroxyacetone phosphate. ALDOA contributes to various cellular functions such as muscle maintenance, r...

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Bibliographic Details
Published in:PloS one 2014-01, Vol.9 (1), p.e85804-e85804
Main Authors: Du, Sha, Guan, Zhuzhu, Hao, Lihong, Song, Yang, Wang, Lan, Gong, Linlin, Liu, Lu, Qi, Xiaoyu, Hou, Zhaoyuan, Shao, Shujuan
Format: Article
Language:English
Subjects:
Actin
Adult
Aged
Aldolase
Amino Acid Sequence
Anemia
Animals
Biology
Biomarkers, Tumor - metabolism
Cancer metastasis
Carcinoma, Squamous Cell - enzymology
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - secondary
Cell Line, Tumor
Cell migration
Cell size
Cytoplasm - enzymology
Dihydroxyacetone
Dihydroxyacetone phosphate
Drug development
Embryology
Enzymes
Female
Fructose
Fructose-1,6-diphosphate
Fructose-bisphosphate aldolase
Fructose-Bisphosphate Aldolase - metabolism
Glycolysis
Histology
Humans
Kaplan-Meier Estimate
Laboratories
Liver cancer
Lung cancer
Lung carcinoma
Lung Neoplasms - enzymology
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Male
Mass spectrometry
Medicine
Metabolism
Metastases
Metastasis
Mice
Mice, Nude
Middle Aged
Molecular Sequence Data
Muscle contraction
Muscle proteins
Muscles
Mutation
Neoplasm Grading
Neoplasm Transplantation
Phosphates
Prognosis
Proteins
Proteomics
Scientific imaging
Skeletal muscle
Squamous cell carcinoma
Stem cells
Thoracic surgery
Tumorigenesis
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Summary:Fructose-bisphosphate aldolase A (ALDOA) is a key enzyme in glycolysis and is responsible for catalyzing the reversible conversion of fructose-1,6-bisphosphate to glyceraldehydes-3-phosphate and dihydroxyacetone phosphate. ALDOA contributes to various cellular functions such as muscle maintenance, regulation of cell shape and mobility, striated muscle contraction, actin filament organization and ATP biosynthetic process. Here, we reported that ALDOA is a highly expressed in lung squamous cell carcinoma (LSCC) and its expression level is correlated with LSCC metastasis, grades, differentiation status and poor prognosis. Depletion of ALDOA expression in the lung squamous carcinoma NCI-H520 cells reduces the capabilities of cell motility and tumorigenesis. These data suggest that ALDOA could be a potential marker for LSCC metastasis and a therapeutic target for drug development.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0085804