Higher education moderates the effect of T2 lesion load and third ventricle width on cognition in multiple sclerosis

Previous work suggested greater intellectual enrichment might moderate the negative impact of brain atrophy on cognition. This awaits confirmation in independent cohorts including investigation of the role of T2-lesion load (T2-LL), which is another important determinant of cognition in MS. We here...

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Published in:PloS one 2014-01, Vol.9 (1), p.e87567-e87567
Main Authors: Pinter, Daniela, Sumowski, James, DeLuca, John, Fazekas, Franz, Pichler, Alexander, Khalil, Michael, Langkammer, Christian, Fuchs, Siegrid, Enzinger, Christian
Format: Article
Language:English
Subjects:
Adult
Archives & records
Atrophy
Atrophy - pathology
Batteries
Biology
Brain
Brain research
Cognition
Cognition & reasoning
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Cognitive ability
Drugs
Education
Educational attainment
Educational Status
Female
Gender differences
Higher education
Humans
Hypotheses
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Medical research
Medicine
Middle Aged
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - physiopathology
Neurology
Neuropsychological Tests
Neurosciences
NMR
Nuclear magnetic resonance
Patients
Regression Analysis
Social and Behavioral Sciences
Standard deviation
Studies
Substantia alba
Thalamus
Third Ventricle - pathology
Variables
Ventricle
Ventricles (cerebral)
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cited_by cdi_FETCH-LOGICAL-c692t-661ccbfd770af655a81e2cae3a129f6732990ebbcfe742b975f9649211c114403
cites cdi_FETCH-LOGICAL-c692t-661ccbfd770af655a81e2cae3a129f6732990ebbcfe742b975f9649211c114403
container_end_page e87567
container_issue 1
container_start_page e87567
container_title PloS one
container_volume 9
creator Pinter, Daniela
Sumowski, James
DeLuca, John
Fazekas, Franz
Pichler, Alexander
Khalil, Michael
Langkammer, Christian
Fuchs, Siegrid
Enzinger, Christian
description Previous work suggested greater intellectual enrichment might moderate the negative impact of brain atrophy on cognition. This awaits confirmation in independent cohorts including investigation of the role of T2-lesion load (T2-LL), which is another important determinant of cognition in MS. We here thus aimed to test this cognitive reserve hypothesis by investigating whether educational attainment (EA) moderates the negative effects of both brain atrophy and T2-LL on cognitive function in a large sample of MS patients. 137 patients participated in the study. Cognition was assessed by the "Brief Repeatable Battery of Neuropsychological Tests." T2-LL, normalized brain volume (global volume loss) and third ventricle width (regional volume loss) served as MRI markers. Both T2-LL and atrophy predicted worse cognition, with a stronger effect of T2-LL. Higher EA (as assessed by years of education) also predicted better cognition. Interactions showed that the negative effects of T2-LL and regional brain atrophy were moderated by EA. In a cohort with different stages of MS, higher EA attenuated the negative effects of white matter lesion burden and third ventricle width (suggestive of thalamic atrophy) on cognitive performance. Actively enhancing cognitive reserve might thus be a means to reduce or prevent cognitive problems in MS in parallel to disease modifying drugs.
doi_str_mv 10.1371/journal.pone.0087567
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identifier ISSN: 1932-6203
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issn 1932-6203
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language eng
recordid cdi_plos_journals_1492015089
source NCBI_PubMed Central（免费）; Publicly Available Content Database
subjects Adult
Archives & records
Atrophy
Atrophy - pathology
Batteries
Biology
Brain
Brain research
Cognition
Cognition & reasoning
Cognition Disorders - etiology
Cognition Disorders - physiopathology
Cognitive ability
Drugs
Education
Educational attainment
Educational Status
Female
Gender differences
Higher education
Humans
Hypotheses
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Medical research
Medicine
Middle Aged
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - physiopathology
Neurology
Neuropsychological Tests
Neurosciences
NMR
Nuclear magnetic resonance
Patients
Regression Analysis
Social and Behavioral Sciences
Standard deviation
Studies
Substantia alba
Thalamus
Third Ventricle - pathology
Variables
Ventricle
Ventricles (cerebral)
title Higher education moderates the effect of T2 lesion load and third ventricle width on cognition in multiple sclerosis
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