Serum CXCL16 as a novel marker of renal injury in type 2 diabetes mellitus

Soluble C-X-C chemokine ligand 16 (CXCL16), a scavenger receptor for oxidized low density lipoprotein, has been shown to promote atherogenic effects in vivo and to predict long-term mortality in acute coronary syndrome. The aim of this study was to explore the association of circulating CXCL16 level...

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Bibliographic Details
Published in:PloS one 2014-01, Vol.9 (1), p.e87786-e87786
Main Authors: Zhao, Leping, Wu, Fan, Jin, Leigang, Lu, Tingting, Yang, Lihui, Pan, Xuebo, Shao, Chuanfeng, Li, Xiaokun, Lin, Zhuofeng
Format: Article
Language:English
Subjects:
Albumin
Analysis
Biology
Biomarkers - blood
Blood
Blood Urea Nitrogen
Body mass
Cardiovascular disease
Chemokine CXCL16
Chemokines
Chemokines, CXC - blood
Cholesterol
Coronary heart disease
Creatinine
Creatinine - blood
CXCL16 protein
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetic nephropathies
Diabetic Nephropathies - blood
Diabetic Nephropathies - etiology
Diabetic nephropathy
Engineering research
Family medical history
Female
Filtrate
Health aspects
High density lipoprotein
Hospitals
Humans
Immunoassay
Immunology
Kidney diseases
Kidney transplantation
Laboratories
Ligands
Low density lipoprotein
Low density lipoproteins
Male
Medical research
Medicine
Middle Aged
Nephrology
Nephropathy
Patients
Pharmaceuticals
Pharmacy
Prognosis
Proteinuria
Proteinuria - blood
Proteinuria - etiology
Receptor density
Receptors, Scavenger - blood
Regression analysis
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - etiology
Rodents
Scavenger receptors
Society
Statistical analysis
Studies
Trans fatty acids
Type 2 diabetes
Urea
Uric acid
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Summary:Soluble C-X-C chemokine ligand 16 (CXCL16), a scavenger receptor for oxidized low density lipoprotein, has been shown to promote atherogenic effects in vivo and to predict long-term mortality in acute coronary syndrome. The aim of this study was to explore the association of circulating CXCL16 levels with diabetic subjects with and without renal disease. One hundred twenty Chinese subjects, which included patients with type 2 diabetes mellitus (T2DM), diabetic nephropathy (DN), and CKD, as well as healthy controls, were enrolled in this study. Serum CXCL16 levels were examined by immunoassay and other clinical biochemical parameters were tested based on standard methods. Our results indicated that, HDL and LDL cholesterol levels are significantly different in DN but not in T2D patients in comparison with healthy subjects. On the other hand, Serum CXCL16 levels were significantly increased in DN subjects compared with age and gender matched healthy and T2DM subjects (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0087786