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Phthalate levels in cord blood are associated with preterm delivery and fetal growth parameters in Chinese women
Data concerning the effects of phthalate exposure on preterm delivery and fetal growth are limited in humans. In this paper, we assessed the relationship between 15 phthalate levels in cord blood and preterm delivery and fetal growth parameters in 207 Chinese women going into labor. Exposure to phth...
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Published in: | PloS one 2014-02, Vol.9 (2), p.e87430-e87430 |
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creator | Huang, Yujing Li, Junnan Garcia, Jose M Lin, Hui Wang, Yanzhou Yan, Ping Wang, Lingqiao Tan, Yao Luo, Jiaohua Qiu, Zhiqun Chen, Ji-an Shu, Weiqun |
description | Data concerning the effects of phthalate exposure on preterm delivery and fetal growth are limited in humans. In this paper, we assessed the relationship between 15 phthalate levels in cord blood and preterm delivery and fetal growth parameters in 207 Chinese women going into labor. Exposure to phthalates except DCHP was associated with gestational age reduction and preterm delivery (p |
doi_str_mv | 10.1371/journal.pone.0087430 |
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In this paper, we assessed the relationship between 15 phthalate levels in cord blood and preterm delivery and fetal growth parameters in 207 Chinese women going into labor. Exposure to phthalates except DCHP was associated with gestational age reduction and preterm delivery (p<0.05). There were associations between phthalates and fetal growth parameters, many of which disappeared when analyses were adjusted for gestational age, especially in male infants (Only DEEP was associated with birth weight; DEP, DNHP, BBP, DNP with abdominal circumference; DEP, DBP, DCHP, DEHP with femur length in female infants. And DPP, DBEP was associated with birth length in male infants. p<0.05). This study indicates that prenatal exposure to phthalates is associated with younger gestational age and preterm delivery. Also, phthalate exposure may adversely affect fetal growth parameters via gestational age reduction and preterm delivery with a significant gender effect.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0087430</identifier><identifier>PMID: 24503621</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Asian Continental Ancestry Group ; Biology ; Birth Weight ; Blood ; Breastfeeding & lactation ; China ; Consent ; Cord blood ; Endocrinology ; Environmental health ; Esters ; Esters - blood ; Exposure ; Family medical history ; Female ; Femur ; Fetal Blood - metabolism ; Fetal Development ; Fetuses ; Gallbladder diseases ; Gestational Age ; Growth ; Gynecology ; Hospitals ; Humans ; Hygiene ; Infant, Newborn ; Infants ; Inflammatory diseases ; Male ; Medicine ; Metabolites ; Molecular weight ; Obstetrics ; Phthalate plasticizers ; Phthalates ; Phthalic Acids - blood ; Pregnancy ; Pregnancy complications ; Pregnant Women ; Premature birth ; Premature Birth - blood ; Prenatal experience ; Prenatal exposure ; Preventive medicine ; Reduction ; Rodents ; Studies ; Urine ; Womens health</subject><ispartof>PloS one, 2014-02, Vol.9 (2), p.e87430-e87430</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Huang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Huang et al 2014 Huang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6070-b489bc899b1ffb7b59774de4a035d64f75f4591a338408bc186e586f7a39eb33</citedby><cites>FETCH-LOGICAL-c6070-b489bc899b1ffb7b59774de4a035d64f75f4591a338408bc186e586f7a39eb33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1494399999/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1494399999?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24503621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chen, Aimin</contributor><creatorcontrib>Huang, Yujing</creatorcontrib><creatorcontrib>Li, Junnan</creatorcontrib><creatorcontrib>Garcia, Jose M</creatorcontrib><creatorcontrib>Lin, Hui</creatorcontrib><creatorcontrib>Wang, Yanzhou</creatorcontrib><creatorcontrib>Yan, Ping</creatorcontrib><creatorcontrib>Wang, Lingqiao</creatorcontrib><creatorcontrib>Tan, Yao</creatorcontrib><creatorcontrib>Luo, Jiaohua</creatorcontrib><creatorcontrib>Qiu, Zhiqun</creatorcontrib><creatorcontrib>Chen, Ji-an</creatorcontrib><creatorcontrib>Shu, Weiqun</creatorcontrib><title>Phthalate levels in cord blood are associated with preterm delivery and fetal growth parameters in Chinese women</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Data concerning the effects of phthalate exposure on preterm delivery and fetal growth are limited in humans. In this paper, we assessed the relationship between 15 phthalate levels in cord blood and preterm delivery and fetal growth parameters in 207 Chinese women going into labor. Exposure to phthalates except DCHP was associated with gestational age reduction and preterm delivery (p<0.05). There were associations between phthalates and fetal growth parameters, many of which disappeared when analyses were adjusted for gestational age, especially in male infants (Only DEEP was associated with birth weight; DEP, DNHP, BBP, DNP with abdominal circumference; DEP, DBP, DCHP, DEHP with femur length in female infants. And DPP, DBEP was associated with birth length in male infants. p<0.05). This study indicates that prenatal exposure to phthalates is associated with younger gestational age and preterm delivery. Also, phthalate exposure may adversely affect fetal growth parameters via gestational age reduction and preterm delivery with a significant gender effect.</description><subject>Age</subject><subject>Asian Continental Ancestry Group</subject><subject>Biology</subject><subject>Birth Weight</subject><subject>Blood</subject><subject>Breastfeeding & lactation</subject><subject>China</subject><subject>Consent</subject><subject>Cord blood</subject><subject>Endocrinology</subject><subject>Environmental health</subject><subject>Esters</subject><subject>Esters - blood</subject><subject>Exposure</subject><subject>Family medical history</subject><subject>Female</subject><subject>Femur</subject><subject>Fetal Blood - metabolism</subject><subject>Fetal Development</subject><subject>Fetuses</subject><subject>Gallbladder diseases</subject><subject>Gestational Age</subject><subject>Growth</subject><subject>Gynecology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hygiene</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Inflammatory diseases</subject><subject>Male</subject><subject>Medicine</subject><subject>Metabolites</subject><subject>Molecular weight</subject><subject>Obstetrics</subject><subject>Phthalate plasticizers</subject><subject>Phthalates</subject><subject>Phthalic Acids - blood</subject><subject>Pregnancy</subject><subject>Pregnancy complications</subject><subject>Pregnant Women</subject><subject>Premature birth</subject><subject>Premature Birth - blood</subject><subject>Prenatal experience</subject><subject>Prenatal exposure</subject><subject>Preventive medicine</subject><subject>Reduction</subject><subject>Rodents</subject><subject>Studies</subject><subject>Urine</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk99v0zAQxyMEYmPwHyCwhITgocWOnV8vSFPFj0qThmDi1To7l8aVE3d22rL_nqTNpgbtAfvB1vlz3zuffVH0mtE54xn7tHZb34Kdb1yLc0rzTHD6JDpnBY9naUz505P9WfQihDWlCc_T9Hl0FouE8jRm59HmR93VYKFDYnGHNhDTEu18SZR1riTgkUAITpseKcnedDXZeOzQN6REa3bo7wi0JamwA0tW3u0HAjw0A3SQW9SmxYBk7xpsX0bPKrABX43rRXTz9cvN4vvs6vrbcnF5NdMpzehMibxQOi8KxapKZSopskyUKIDypExFlSWVSAoGnOeC5kqzPMUkT6sMeIGK84vo7VF2Y12QY62CZKIQvBhGTyyPROlgLTfeNODvpAMjDwbnVxJ8Z7RFmVexriBmXCktSoWQAmiRqt7EYlSi1_o8RtuqBkuNbefBTkSnJ62p5crtJC8YT9kg8GEU8O52i6GTjQkarYUW3faQd09Sccj73T_o47cbqRX0FzBt5fq4ehCVlyLLc85iPlDzR6h-ltgY3X-syvT2icPHiUPPdPinW8E2BLn89fP_2evfU_b9CVsj2K4Ozm4749owBcUR1N6F4LF6KDKjcuiL-2rIoS_k2Be925vTB3pwum8E_heElAmV</recordid><startdate>20140204</startdate><enddate>20140204</enddate><creator>Huang, Yujing</creator><creator>Li, Junnan</creator><creator>Garcia, Jose M</creator><creator>Lin, Hui</creator><creator>Wang, Yanzhou</creator><creator>Yan, Ping</creator><creator>Wang, Lingqiao</creator><creator>Tan, Yao</creator><creator>Luo, Jiaohua</creator><creator>Qiu, Zhiqun</creator><creator>Chen, Ji-an</creator><creator>Shu, Weiqun</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140204</creationdate><title>Phthalate levels in cord blood are associated with preterm delivery and fetal growth parameters in Chinese women</title><author>Huang, Yujing ; Li, Junnan ; Garcia, Jose M ; Lin, Hui ; Wang, Yanzhou ; Yan, Ping ; Wang, Lingqiao ; Tan, Yao ; Luo, Jiaohua ; Qiu, Zhiqun ; Chen, Ji-an ; Shu, Weiqun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6070-b489bc899b1ffb7b59774de4a035d64f75f4591a338408bc186e586f7a39eb33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Age</topic><topic>Asian Continental Ancestry Group</topic><topic>Biology</topic><topic>Birth Weight</topic><topic>Blood</topic><topic>Breastfeeding & lactation</topic><topic>China</topic><topic>Consent</topic><topic>Cord blood</topic><topic>Endocrinology</topic><topic>Environmental health</topic><topic>Esters</topic><topic>Esters - 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In this paper, we assessed the relationship between 15 phthalate levels in cord blood and preterm delivery and fetal growth parameters in 207 Chinese women going into labor. Exposure to phthalates except DCHP was associated with gestational age reduction and preterm delivery (p<0.05). There were associations between phthalates and fetal growth parameters, many of which disappeared when analyses were adjusted for gestational age, especially in male infants (Only DEEP was associated with birth weight; DEP, DNHP, BBP, DNP with abdominal circumference; DEP, DBP, DCHP, DEHP with femur length in female infants. And DPP, DBEP was associated with birth length in male infants. p<0.05). This study indicates that prenatal exposure to phthalates is associated with younger gestational age and preterm delivery. Also, phthalate exposure may adversely affect fetal growth parameters via gestational age reduction and preterm delivery with a significant gender effect.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24503621</pmid><doi>10.1371/journal.pone.0087430</doi><tpages>e87430</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Age Asian Continental Ancestry Group Biology Birth Weight Blood Breastfeeding & lactation China Consent Cord blood Endocrinology Environmental health Esters Esters - blood Exposure Family medical history Female Femur Fetal Blood - metabolism Fetal Development Fetuses Gallbladder diseases Gestational Age Growth Gynecology Hospitals Humans Hygiene Infant, Newborn Infants Inflammatory diseases Male Medicine Metabolites Molecular weight Obstetrics Phthalate plasticizers Phthalates Phthalic Acids - blood Pregnancy Pregnancy complications Pregnant Women Premature birth Premature Birth - blood Prenatal experience Prenatal exposure Preventive medicine Reduction Rodents Studies Urine Womens health |
title | Phthalate levels in cord blood are associated with preterm delivery and fetal growth parameters in Chinese women |
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