Prevalence of anti-citrullinated protein antibodies (ACPA) in patients with diffuse large B-cell lymphoma (DLBCL): a case-control study

Antibodies against citrullinated proteins (ACPA) have been recognised as the most specific serum marker for rheumatoid arthritis. However, serum autoantibodies such as anti-nuclear antibodies have also been detected in the sera of different lymphatic malignancies without accompanying rheumatologic d...

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Bibliographic Details
Published in:PloS one 2014-02, Vol.9 (2), p.e88177-e88177
Main Authors: Assmann, Gunter, Shihadeh, Klara, Poeschel, Viola, Murawski, Niels, Conigliarou, Jutta, Ong, Mei Fang, Pfreundschuh, Michael
Format: Article
Language:English
Subjects:
Antibodies
Arthritis
Autoantibodies
Autoantibodies - blood
B-cell lymphoma
Blood & organ donations
Cardiovascular disease
Case-Control Studies
Chemotherapy
Citrulline
Drug dosages
Epidemiology
Family medical history
Female
Gene therapy
Humans
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Immunoglobulins
Internal medicine
Lymphocytes B
Lymphoma
Lymphoma, Large B-Cell, Diffuse - blood
Lymphoma, Large B-Cell, Diffuse - immunology
Lymphoma, Large B-Cell, Diffuse - mortality
Male
Medical prognosis
Medical schools
Medicine
Middle Aged
Patients
Peptides
Peptides, Cyclic - immunology
Population
Prognosis
Proteins
Rheumatoid arthritis
Seroepidemiologic Studies
Statistical analysis
Statistical tests
Stem cells
Studies
Subgroups
Survival
Survival Rate
Tumor necrosis factor-TNF
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Description
Summary:Antibodies against citrullinated proteins (ACPA) have been recognised as the most specific serum marker for rheumatoid arthritis. However, serum autoantibodies such as anti-nuclear antibodies have also been detected in the sera of different lymphatic malignancies without accompanying rheumatologic disease. Therefore, we conducted a study to evaluate the prevalence of ACPA in diffuse large B-cell non-Hodgkin lymphoma (DLBCL). Sera of 395 DLBCL patients and 258 age-matched healthy controls were investigated to evaluate the prevalence of ACPA and RF. ACPA-positive data were stratified into subgroups of RF positivity and established prognostic parameters for DLBCL, including overall survival. In addition, the ACPA serum concentrations levels were compared to an ACPA-positive RA cohort (n = 175). The statistics were performed with χ2 test and Mann- Whitney-U test; Kaplan-Meyer curves (log rank test) were used to analyse the overall survival. P-value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0088177