Early life socioeconomic circumstance and late life brain hyperintensities--a population based cohort study

There have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors,...

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Bibliographic Details
Published in:PloS one 2014-02, Vol.9 (2), p.e88969-e88969
Main Authors: Murray, Alison D, McNeil, Christopher J, Salarirad, Sima, Whalley, Lawrence J, Staff, Roger T
Format: Article
Language:English
Subjects:
Aged
Alzheimer's disease
Alzheimers disease
Analysis of Variance
Brain
Brain research
Cardiovascular disease
Cardiovascular diseases
Cerebrovascular Disorders - epidemiology
Cerebrovascular Disorders - pathology
Children
Classification
Cognition & reasoning
Cognitive ability
Cohort analysis
Cohort Studies
Collaboration
Communities
Correlation
Dementia
Dementia disorders
Education
Ethics
Fathers
Fetuses
Health risk assessment
Humans
Hypertension
Intelligence
Lesions
Magnetic resonance
Magnetic Resonance Imaging
Manual workers
Medical imaging
Medicine
Neuroimaging
NMR
Nuclear magnetic resonance
Occupations
Population studies
Population-based studies
Risk analysis
Risk factors
Scotland - epidemiology
Socio-economic aspects
Socioeconomic Factors
Socioeconomics
Stroke
Studies
Substantia alba
Womens health
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Summary:There have been many reports confirming the association between lower childhood socioeconomic circumstance and cardiovascular disease but evidence for links with cerebrovascular disease is contradictory. Hyperintensities on brain magnetic resonance imaging are associated with vascular risk factors, cognitive decline, dementia and death. However, the relationship between childhood socioeconomic circumstance and these lesions is unclear. To test the hypothesis that childhood socioeconomic circumstance is associated with late life hyperintensity burden and that neither adult socioeconomic circumstance nor change in socioeconomic circumstance during life influence this effect. Cohort study. Community. 227 community dwelling members of the 1936 Aberdeen Birth Cohort aged 68 years, who were free from dementia. Relationship between early life socioeconomic circumstance (paternal occupation) and abundance of late life brain hyperintensities. We find significant negative correlations between childhood socioeconomic circumstance and white matter hyperintensities (ρ = -0.18, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0088969