Maternal obesity affects fetal neurodevelopmental and metabolic gene expression: a pilot study

One in three pregnant women in the United States is obese. Their offspring are at increased risk for neurodevelopmental and metabolic morbidity. Underlying molecular mechanisms are poorly understood. We performed a global gene expression analysis of mid-trimester amniotic fluid cell-free fetal RNA i...

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Bibliographic Details
Published in:PloS one 2014-02, Vol.9 (2), p.e88661-e88661
Main Authors: Edlow, Andrea G, Vora, Neeta L, Hui, Lisa, Wick, Heather C, Cowan, Janet M, Bianchi, Diana W
Format: Article
Language:English
Subjects:
Abnormalities
Acids
Adult
Age
Amniocentesis
Amniotic fluid
Analysis
Apolipoproteins
Apoptosis
Biology
Body mass
Body mass index
Cell death
Central nervous system
Cerebral cortex
Cerebrum
Computational Biology
Epigenetics
Estrogens
Female
Fetus - embryology
Fetus - metabolism
Fetuses
Fos protein
Gene expression
Gene Expression Regulation, Developmental
Genes
Genomes
Genomics
Gestational age
Gynecology
Humans
Hybridization
Inflammation
Laboratories
Medicine
Metabolic syndrome
Middle Aged
Molecular modelling
Morbidity
Mothers
Nervous System - embryology
Neurodevelopmental disorders
Obesity
Obstetrics
Offspring
Oligonucleotide Array Sequence Analysis
Organ Specificity
Pilot Projects
Pregnancy
Pregnancy Trimester, Second
Pregnant women
Regulators
Ribonucleic acid
RNA
Rodents
Signal transduction
Stat3 protein
Studies
Transcription activation
Womens health
Xenoestrogens
Young Adult
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Description
Summary:One in three pregnant women in the United States is obese. Their offspring are at increased risk for neurodevelopmental and metabolic morbidity. Underlying molecular mechanisms are poorly understood. We performed a global gene expression analysis of mid-trimester amniotic fluid cell-free fetal RNA in obese versus lean pregnant women. This prospective pilot study included eight obese (BMI≥30) and eight lean (BMI
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0088661