Postsynaptic odorant concentration dependent inhibition controls temporal properties of spike responses of projection neurons in the moth antennal lobe

Although odorant concentration-response characteristics of olfactory neurons have been widely investigated in a variety of animal species, the effect of odorant concentration on neural processing at circuit level is still poorly understood. Using calcium imaging in the silkmoth (Bombyx mori) pheromo...

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Bibliographic Details
Published in:PloS one 2014-02, Vol.9 (2), p.e89132
Main Authors: Fujiwara, Terufumi, Kazawa, Tomoki, Haupt, Stephan Shuichi, Kanzaki, Ryohei
Format: Article
Language:English
Subjects:
Animal species
Animals
Antennal lobe
Arthropod Antennae - innervation
Bees
Biology
Bombyx
Brain research
Butterflies & moths
Calcium
Calcium - metabolism
Calcium imaging
Dendrites
Drosophila
Electrophysiology
Firing pattern
Information processing
Information science
Inhibition
Insects
Interneurons
Male
Medicine
Nerve Net - metabolism
Neural Inhibition - physiology
Neurons
Odorants
Olfactory Cortex - cytology
Olfactory Cortex - physiology
Olfactory neurons
Olfactory Pathways - physiology
Olfactory Receptor Neurons - metabolism
Pheromones
Receptors, Odorant - metabolism
Science
Senses
Synapses - metabolism
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Summary:Although odorant concentration-response characteristics of olfactory neurons have been widely investigated in a variety of animal species, the effect of odorant concentration on neural processing at circuit level is still poorly understood. Using calcium imaging in the silkmoth (Bombyx mori) pheromone processing circuit of the antennal lobe (AL), we studied the effect of odorant concentration on second-order projection neuron (PN) responses. While PN calcium responses of dendrites showed monotonic increases with odorant concentration, calcium responses of somata showed decreased responses at higher odorant concentrations due to postsynaptic inhibition. Simultaneous calcium imaging and electrophysiology revealed that calcium responses of PN somata but not dendrites reflect spiking activity. Inhibition shortened spike response duration rather than decreasing peak instantaneous spike frequency (ISF). Local interneurons (LNs) that were specifically activated at high odorant concentrations at which PN responses were suppressed are the putative source of inhibition. Our results imply the existence of an intraglomerular mechanism that preserves time resolution in olfactory processing over a wide odorant concentration range.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0089132