Genetic polymorphism of apolipoprotein A5 gene and susceptibility to type 2 diabetes mellitus: a meta-analysis of 15,137 subjects

Several studies have investigated whether the polymorphism in the apolipoprotein A5 (APOA5) is associated with type 2 diabetes mellitus (T2DM) risk. However, those studies have produced inconsistent results. The purpose of this study was to investigate whether the APOA5 -1131T/C polymorphism (rs6627...

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Bibliographic Details
Published in:PloS one 2014-02, Vol.9 (2), p.e89167-e89167
Main Authors: Yin, Yan-Wei, Sun, Qian-Qian, Wang, Pei-Jian, Qiao, Li, Hu, Ai-Min, Liu, Hong-Li, Wang, Qi, Hou, Zhi-Zhen
Format: Article
Language:English
Subjects:
Alleles
Alzheimer's disease
Analysis
Apolipoprotein A-V
Apolipoproteins
Apolipoproteins A - genetics
Asian Continental Ancestry Group - genetics
Asian Continental Ancestry Group - statistics & numerical data
Biology
Cardiovascular disease
Case-Control Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - genetics
Disease susceptibility
Epidemiology
Ethnicity
European Continental Ancestry Group - genetics
European Continental Ancestry Group - statistics & numerical data
Gene polymorphism
Genetic aspects
Genetic Heterogeneity
Genetic polymorphisms
Genetic Predisposition to Disease
Genomes
Health risks
Hospitals
Humans
Medical ethics
Medicine
Meta-analysis
Metabolic syndrome
Minority & ethnic groups
Polymorphism
Polymorphism, Single Nucleotide
Population
Population (statistical)
Quality
Risk
Scientific papers
Search engines
Statistical analysis
Studies
Type 2 diabetes
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Summary:Several studies have investigated whether the polymorphism in the apolipoprotein A5 (APOA5) is associated with type 2 diabetes mellitus (T2DM) risk. However, those studies have produced inconsistent results. The purpose of this study was to investigate whether the APOA5 -1131T/C polymorphism (rs662799) confers significant susceptibility to T2DM using a meta-analysis. PubMed, Embase, Web of Science, Cochrane database, CBMdisc, CNKI and Google Scholar were searched to get the genetic association studies. All statistical analyses were done with Stata 11.0. A total of 19 studies included 4,767 T2DM cases and 10,370 controls (four studies involving 555 T2DM cases and 2958 controls were performed among Europeans and 15 studies involving 4212 T2DM cases and 7412 controls were performed among Asians) were combined showing significant association between the APOA5 -1131T/C polymorphism and T2DM risk (for C allele vs. T allele: OR = 1.28, 95% CI = 1.17-1.40, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0089167