Acute lymphoid leukemia cells with greater stem cell antigen-1 (Ly6a/Sca-1) expression exhibit higher levels of metalloproteinase activity and are more aggressive in vivo

Stem cell antigen-1 (Ly6a/Sca-1) is a gene that is expressed in activated lymphocytes, hematopoietic stem cells and stem cells of a variety of tissues in mice. Despite decades of study its functions remain poorly defined. These studies explored the impact of expression of this stem cell associated g...

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Bibliographic Details
Published in:PloS one 2014-02, Vol.9 (2), p.e88966-e88966
Main Authors: Hsu, Yu-Chiao, Mildenstein, Kurt, Hunter, Kordell, Tkachenko, Olena, Mullen, Craig A
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Animal tissues
Animals
Antigens
Antigens, Ly - metabolism
Behavior
Biology
Biotechnology
Blotting, Western
Cancer
Cancer genetics
Cell Line, Tumor
Collagen
Drug Combinations
Experiments
Flow Cytometry
Gene expression
Genetic aspects
Genetic Vectors - genetics
Hematopoietic stem cells
Laboratory animals
Laminin
Leukemia
Lymphatic leukemia
Lymphocytes
Matrix metalloproteinases
Medicine
Membrane Proteins - metabolism
Metalloproteases - metabolism
Metalloproteinase
Metastasis
Mice
Mice, Inbred C57BL
Neoplasm Invasiveness - physiopathology
Pediatrics
Plasmids
Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma - physiopathology
Prostate
Proteins
Proteoglycans
Statistics, Nonparametric
Stem cell transplantation
Stem cells
Stroma
Tumor Microenvironment - physiology
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Summary:Stem cell antigen-1 (Ly6a/Sca-1) is a gene that is expressed in activated lymphocytes, hematopoietic stem cells and stem cells of a variety of tissues in mice. Despite decades of study its functions remain poorly defined. These studies explored the impact of expression of this stem cell associated gene in acute lymphoid leukemia. Higher levels of Ly6a/Sca-1 expression led to more aggressive leukemia growth in vivo and earlier death of hosts. Leukemias expressing higher levels of Ly6a/Sca-1 exhibited higher levels of matrix metalloproteinases. The results suggest the hypothesis that the more aggressive behavior of Ly6a/Sca-1 expressing leukemias is due at least in part to greater capacity to degrade microenvironmental stroma and invade tissues.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0088966