Repair of microdamage in osteonal cortical bone adjacent to bone screw

Up to date, little is known about the repair mode of microdamage in osteonal cortical bone resulting from bone screw implantation. In this study, self-tapping titanium cortical bone screws were inserted into the tibial diaphyses of 24 adult male rabbits. The animals were sacrificed at 1 day, 2 weeks...

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Bibliographic Details
Published in:PloS one 2014-02, Vol.9 (2), p.e89343-e89343
Main Authors: Wang, Lei, Ye, Tingjun, Deng, Lianfu, Shao, Jin, Qi, Jin, Zhou, Qi, Wei, Li, Qiu, Shijing
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Biocompatibility
Biology
Biomedical materials
Bone remodeling
Bone Remodeling - physiology
Bone resorption
Bone Resorption - etiology
Bone Resorption - prevention & control
Bone Screws - adverse effects
Bone surgery
Canals
Canals (anatomy)
Confocal microscopy
Cortical bone
Disease prevention
Fracture mechanics
Fractures
Haversian System - physiology
Implantation
Laboratories
Leg Injuries - etiology
Leg Injuries - prevention & control
Male
Medicine
Microscopy
Microscopy, Confocal
Morphology
Orthopedics
Osteoporosis
Physical characteristics
Rabbits
Repair
Surgery
Transplants & implants
Veterinary Science
Wound Healing - physiology
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Summary:Up to date, little is known about the repair mode of microdamage in osteonal cortical bone resulting from bone screw implantation. In this study, self-tapping titanium cortical bone screws were inserted into the tibial diaphyses of 24 adult male rabbits. The animals were sacrificed at 1 day, 2 weeks, 1 month and 2 months after surgery. Histomorphometric measurement and confocal microscopy were performed on basic fuchsin stained bone sections to examine the morphological characteristics of microdamage, bone resorption activity and spatial relationship between microdamage and bone resorption. Diffuse and linear cracks were coexisted in peri-screw bone. Intracortical bone resorption was significantly increased 2 weeks after screw installation and reach to the maximum at 1 month. There was no significant difference in bone resorption between 1-month and 2-months groups. Microdamage was significantly decreased within 1 month after surgery. Bone resorption was predisposed to occur in the region of
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0089343