Higher serum direct bilirubin levels were associated with a lower risk of incident chronic kidney disease in middle aged Korean men

The association between serum bilirubin levels and incident chronic kidney disease (CKD) in the general population is unknown. We aimed to examine the association between serum bilirubin concentration (total, direct, and indirect) and the risk of incident CKD. Longitudinal cohort study of 12,823 Kor...

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Bibliographic Details
Published in:PloS one 2014-02, Vol.9 (2), p.e75178
Main Authors: Ryu, Seungho, Chang, Yoosoo, Zhang, Yiyi, Woo, Hee-Yeon, Kwon, Min-Jung, Park, Hyosoon, Lee, Kyu-Beck, Son, Hee Jung, Cho, Juhee, Guallar, Eliseo
Format: Article
Language:English
Subjects:
Adjustment
Adult
Alcohol
Alcohol use
Analysis of Variance
Angina pectoris
Bilirubin
Bilirubin - blood
Biology
Cardiovascular disease
Chronic kidney failure
Cohort Studies
Disease prevention
Environmental health
Epidemiology
Epidermal growth factor receptors
Family medical history
Gastroenterology
Glomerular Filtration Rate
Health hazards
Health risks
Hospitals
Humans
Hypertension
Incidence
Insulin resistance
Internal medicine
Ischemia
Kidney diseases
Kidney transplantation
Laboratories
Logistic Models
Longitudinal Studies
Male
Medical screening
Medicine
Metabolic syndrome
Middle Aged
Occupational health
Population
Proportional Hazards Models
Proteinuria
Public health
Quartiles
Regression analysis
Regression models
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - epidemiology
Republic of Korea - epidemiology
Review boards
Risk
Risk Factors
Rodents
Studies
Transplants & implants
Workers
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Summary:The association between serum bilirubin levels and incident chronic kidney disease (CKD) in the general population is unknown. We aimed to examine the association between serum bilirubin concentration (total, direct, and indirect) and the risk of incident CKD. Longitudinal cohort study of 12,823 Korean male workers 30 to 59 years old without CKD or proteinuria at baseline participating in medical health checkup program in a large worksite. Study participants were followed for incident CKD from 2002 through 2011. Estimated glomerular filtration rate (eGFR) was estimated by using the CKD-EPI equation. CKD was defined as eGFR
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0075178