Regulation of p53 level by UBE4B in breast cancer

p53 is possibly the most important mammalian tumor suppressor and it is mutated or lost in more than half of all human cancers. The stability of p53 is primarily determined by the RING domain E3 ubiquitin ligase Hdm2, which targets p53 for proteasomal degradation, restraining the potent activity of...

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Published in:PloS one 2014-02, Vol.9 (2), p.e90154
Main Authors: Zhang, Ying, Lv, Yanrong, Zhang, Yongyang, Gao, Haidong
Format: Article
Language:English
Subjects:
Animals
Antigens
Apoptosis
Biology
Biomarkers, Tumor - metabolism
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cancer
Carcinogenesis
Cell cycle
Cell growth
Cell Line, Tumor
Cell survival
Degradation
Enzymes
Female
Fluorides
Gene amplification
Gene Expression Regulation, Neoplastic
Health aspects
Humans
Immunoglobulins
Ligases
Medicine
Mice
Neuroblastoma
p53 Protein
Plasmids
Proteasomes
Proteins
Proteolysis
Proto-Oncogene Proteins c-mdm2 - metabolism
Stability
Surgery
Tumor proteins
Tumor suppressor genes
Tumor Suppressor Protein p53 - metabolism
Tumor Suppressor Proteins - metabolism
Tumorigenesis
Ubiquitin
Ubiquitin-protein ligase
Ubiquitin-Protein Ligase Complexes - metabolism
Ubiquitination
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Lv, Yanrong
Zhang, Yongyang
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description p53 is possibly the most important mammalian tumor suppressor and it is mutated or lost in more than half of all human cancers. The stability of p53 is primarily determined by the RING domain E3 ubiquitin ligase Hdm2, which targets p53 for proteasomal degradation, restraining the potent activity of p53 and enabling cell survival and proliferation. UBE4B has been shown to physically interact with p53 and Hdm2 and to negatively regulate p53 stability and function. However, no one has determined whether UBE4B promotes p53 degradation in breast cancer. In this study, UBE4B promoted the degradation and ubiquitination of p53 to inhibit the apoptosis of cancer cells and promote tumorigenesis. Our results indicate that UBE4B regulates p53 in breast cancer and could be a viable target for developing new therapeutic strategies for breast cancer treatment.
doi_str_mv 10.1371/journal.pone.0090154
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subjects Animals
Antigens
Apoptosis
Biology
Biomarkers, Tumor - metabolism
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cancer
Carcinogenesis
Cell cycle
Cell growth
Cell Line, Tumor
Cell survival
Degradation
Enzymes
Female
Fluorides
Gene amplification
Gene Expression Regulation, Neoplastic
Health aspects
Humans
Immunoglobulins
Ligases
Medicine
Mice
Neuroblastoma
p53 Protein
Plasmids
Proteasomes
Proteins
Proteolysis
Proto-Oncogene Proteins c-mdm2 - metabolism
Stability
Surgery
Tumor proteins
Tumor suppressor genes
Tumor Suppressor Protein p53 - metabolism
Tumor Suppressor Proteins - metabolism
Tumorigenesis
Ubiquitin
Ubiquitin-protein ligase
Ubiquitin-Protein Ligase Complexes - metabolism
Ubiquitination
title Regulation of p53 level by UBE4B in breast cancer
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