Stereotactic body radiotherapy-induced arterial hypervascularity of non-tumorous hepatic parenchyma in patients with hepatocellular carcinoma: potential pitfalls in tumor response evaluation on multiphase computed tomography

To evaluate temporal changes in contrast enhancement patterns of non-tumorous hepatic parenchyma with a focus on arterial hypervascularity on multiphase computed tomography (CT) in patients with hepatocellular carcinoma (HCC) treated with stereotactic body radiotherapy (SBRT). We retrospectively ide...

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Bibliographic Details
Published in:PloS one 2014-02, Vol.9 (2), p.e90327-e90327
Main Authors: Park, Mee Jin, Kim, So Yeon, Yoon, Sang Min, Kim, Jong Hoon, Park, Seong Ho, Lee, Seung Soo, Lee, Yedaun, Lee, Moon-Gyu
Format: Article
Language:English
Subjects:
Aged
Biology
Carcinoma, Hepatocellular - blood supply
Carcinoma, Hepatocellular - diagnosis
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - radiotherapy
Care and treatment
CAT scans
Comparative analysis
Computation
Computed tomography
Contrast Media - chemistry
Drug dosages
Evaluation
Female
Hepatocellular carcinoma
Humans
Identification methods
Liver
Liver - blood supply
Liver - pathology
Liver - radiation effects
Liver cancer
Liver Neoplasms - blood supply
Liver Neoplasms - diagnosis
Liver Neoplasms - pathology
Liver Neoplasms - radiotherapy
Liver transplants
Male
Medical imaging
Medicine
Middle Aged
Multiphase
Parenchyma
Patients
Radiation therapy
Radiosurgery
Radiotherapy
Retrospective Studies
Studies
Tomography, X-Ray Computed - methods
Tumor Microenvironment
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Summary:To evaluate temporal changes in contrast enhancement patterns of non-tumorous hepatic parenchyma with a focus on arterial hypervascularity on multiphase computed tomography (CT) in patients with hepatocellular carcinoma (HCC) treated with stereotactic body radiotherapy (SBRT). We retrospectively identified 61 patients who had undergone multiphase contrast-enhanced CT at one, three, and six months after SBRT. Irradiated versus non-irradiated liver parenchyma was delineated by cross-correlation with the dose-volume histogram of SBRT plan. Serial changes in the contrast enhancement patterns of the irradiated versus non-irradiated liver parenchyma were evaluated by two abdominal radiologists in consensus. We compared the frequency of the contrast enhancement patterns according to the follow-up period using the Fisher-Freeman-Halton exact test. The irradiated non-tumorous hepatic parenchyma showed that the prevalence of arterial hypervascularity increased during the follow-up period (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0090327