Diet as a risk factor for pneumococcal carriage and otitis media: a cross-sectional study among children in day care centers

• Published in: PloS one 2014-03, Vol.9 (3), p.e90585-e90585
• Main Authors: Tapiainen, Terhi, Paalanne, Niko, Arkkola, Tuula, Renko, Marjo, Pokka, Tytti, Kaijalainen, Tarja, Uhari, Matti
• Format: Article
• Language: English
• Subjects: Bacteria; Berries; Biofilms; Biology; Carbohydrates; Carcinogens; Carrier State; Child; Child, Preschool; Children; Children & youth; Consumption; Cross-Sectional Studies; Day care centers; Day Care, Medical; Dental caries; Diet; Dietary intake; Ear diseases; Families & family life; Feeding Behavior; Female; Food; Fruits; Fruits (Food); Gene expression; Humans; Hypotheses; Immunization; Male; Media; Medical research; Medicine; Mouth Mucosa - microbiology; Nutrition research; Otitis media; Otitis Media - epidemiology; Otitis Media - microbiology; Parents; Parents & parenting; Pastries; Pediatrics; Pharynx; Pharynx - microbiology; Pneumonia; Principal components analysis; Questionnaires; Regression analysis; Regression coefficients; Risk Factors; Snack foods; Streptococcus infections; Streptococcus mutans; Streptococcus pneumoniae; Sucrose; Sugar; Sweet taste; Vaccines; Vitamin D
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0090585

Pharyngeal bacteria are exposed to different sugar conditions depending on the diet of the child. We hypothesized that dietary factors such as daily intake of carbohydrates could be associated with pneumococcal carriage and the occurrence of otitis media in children. Our study design was a cross-sectional study among 1006 children attending child day care centers. Parents filled in a food frequency questionnaire. Oropharyngeal swabs were collected from each child. The primary outcome was the occurrence of pneumococcal carriage and the secondary outcome the number of acute otitis media episodes during life. Principal component analysis was used to group dietary intake into nine factors. The models were adjusted for age, gender of the child and educational level of the mother. The dietary factor which included high consumption of sweet pastries and jam was associated with an increased risk of pneumococcal carriage (OR 1.17, 95% CI 1.01 to 1.36, P-value 0.04). The factor including frequent consumption of fruit and berries was associated with a decreased risk of acute otitis (regression coefficient -0.51, 95% CI -0.98 to -0.03, P=0.04). A high intake of consumption of sweets and snacks (OR 1.36, 95% CI 1.03 to 1.80, P=0.03) was associated with an increased risk of caries. Diet was associated with a risk of pneumococcal carriage and the occurrence of otitis media. Diet may thus be a modifiable risk factor for the occurrence of acute otitis media.