A functional Ser326Cys polymorphism in hOGG1 is associated with noise-induced hearing loss in a Chinese population

• Published in: PloS one 2014-03, Vol.9 (3), p.e89662
• Main Authors: Shen, Huanxi, Cao, Jinglian, Hong, Zhiqiang, Liu, Kai, Shi, Jian, Ding, Lu, Zhang, Hengdong, Du, Cheng, Li, Qian, Zhang, Zhengdong, Zhu, Baoli
• Format: Article
• Language: English
• Subjects: 8-Hydroxyguanine; Adult; Amino Acid Substitution; Auditory defects; Base excision repair; Biology; Case-Control Studies; Cochlea; Deoxyribonucleic acid; Disease susceptibility; DNA; DNA damage; DNA Glycosylases - genetics; Enzymes; Epidemiology; Exposure; Female; Gene Frequency; Gene polymorphism; Genetic aspects; Genetic Association Studies; Genetic polymorphisms; Genetic Predisposition to Disease; Genotypes; Hair cells; Hearing loss; Hearing Loss, Noise-Induced - enzymology; Hearing Loss, Noise-Induced - genetics; Humans; Investigations; Male; Medical research; Medicine; Middle Aged; Noise; Noise control; Noise levels; Occupational exposure; Polymorphism; Polymorphism, Single Nucleotide; Smoking
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0089662

DNA damage to cochlear hair cells caused by 8-oxoguanine (8-oxoG) is essential for the development of noise-induced hearing loss (NIHL). Human 8-oxoG DNA glycosylase1 (hOGG1) is a key enzyme in the base excision repair (BER) pathway that eliminates 8-oxoG. Many epidemiological and functional studies have suggested that the hOGG1 Ser326Cys polymorphism (rs1052133) is associated with many diseases. The purpose of this investigation was to investigate whether the hOGG1 Ser326Cys polymorphism in the human BER pathway is associated with genetic susceptibility to NIHL in a Chinese population. This polymorphism was genotyped among 612 workers with NIHL and 615 workers with normal hearing. We found that individuals with the hOGG1 Cys/Cys genotype had a statistically significantly increased risk of NIHL compared with those who carried the hOGG1 Ser/Ser genotype (adjusted OR=1.59, 95% CI=1.13-2.25) and this increased risk was more pronounced among the workers in the 15- to 25- and >25-year noise exposure time, 85-92 dB(A) noise exposure level, ever smoking, and ever drinking groups, similar effects were also observed in a recessive model. In summary, our data suggested that the hOGG1 Cys/Cys genotype may be a genetic susceptibility marker for NIHL in the Chinese Han population.