ALDH2 and ADH1 genetic polymorphisms may contribute to the risk of gastric cancer: a meta-analysis

We conducted a meta-analysis of case-control studies to determine whether ALDH2, ADH1 and ADH2 genetic polymorphisms contribute to the pathogenesis of gastric cancer. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant art...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2014-03, Vol.9 (3), p.e88779-e88779
Main Authors: Wang, He-Ling, Zhou, Ping-Yi, Liu, Peng, Zhang, Yu
Format: Article
Language:English
Subjects:
ADH1 gene
ADH2 gene
Alcohol Dehydrogenase - genetics
Alcohol use
Aldehyde dehydrogenase
Aldehyde dehydrogenase (NAD)
Aldehyde Dehydrogenase - genetics
Aldehyde Dehydrogenase, Mitochondrial
Alleles
Biology
Cancer
Cancer research
Confidence intervals
Dehydrogenases
Development and progression
Disease susceptibility
Ethanol
Female
Gastric cancer
Gene polymorphism
Genes
Genetic analysis
Genetic aspects
Genetic polymorphisms
Genetic Predisposition to Disease - genetics
Genotype & phenotype
Health aspects
Health risks
Humans
Kinases
Male
Medicine
Meta-analysis
Metabolism
Metabolites
Oxidation
Pathogenesis
Polymorphism
Polymorphism, Genetic - genetics
Risk
Risk factors
Search engines
Stomach cancer
Stomach Neoplasms - genetics
Studies
Surgery
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We conducted a meta-analysis of case-control studies to determine whether ALDH2, ADH1 and ADH2 genetic polymorphisms contribute to the pathogenesis of gastric cancer. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before November 1st, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software. We calculated crude odds ratios (ORs) with their 95% confidence intervals (95%CI) to evaluate their relationships under five genetic models. Seven case-control studies with a total of 2,563 gastric cancer patients and 4,192 healthy controls met the inclusion criteria. Nine common polymorphisms were evaluated, including rs671, rs16941667 and rs886205 in the ALDH2 gene, rs1230025, rs13123099, rs698 and rs1693482 in the ADH1 gene, and rs1229984 and rs17033 in the ADH2 gene. The results of our meta-analysis suggested that ALDH2 genetic polymorphisms might be strongly correlated with an increased risk of gastric cancer (allele model: OR = 1.21, 95%CI: 1.11 ∼ 1.32, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0088779