Comparison of three quality of life instruments in lymphatic filariasis: DLQI, WHODAS 2.0, and LFSQQ

The Global Program to Eliminate Lymphatic Filariasis aims to interrupt transmission of lymphatic filariasis and manage morbidity in people currently living with the disease. A component of morbidity management is improving health-related quality of life (HRQoL) in patients. Measurement of HRQoL in c...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2014-02, Vol.8 (2), p.e2716-e2716
Main Authors: Thomas, Cristina, Narahari, Saravu R, Bose, Kuthaje S, Vivekananda, Kuthaje, Nwe, Steven, West, Dennis P, Kwasny, Mary, Kundu, Roopal V
Format: Article
Language:English
Subjects:
Aged
Comparative analysis
Conferences
Cross-Sectional Studies
Demographic aspects
Disability
Disease
Elephantiasis, Filarial - epidemiology
Elephantiasis, Filarial - psychology
Female
Filariasis
Health aspects
Health Status Indicators
Humans
Intervention
Lymphatic system
Male
Measurement
Medicine
Middle Aged
Morbidity
Patient outcomes
Psychometrics - methods
Quality of life
Quality of Life - psychology
Questionnaires
Statistics, Nonparametric
Surveys and Questionnaires
Validity
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Summary:The Global Program to Eliminate Lymphatic Filariasis aims to interrupt transmission of lymphatic filariasis and manage morbidity in people currently living with the disease. A component of morbidity management is improving health-related quality of life (HRQoL) in patients. Measurement of HRQoL in current management programs is varied because of the lack of a standard HRQoL tool for use in the lymphatic filariasis population. In this study, the psychometric properties of three health status measures were compared when used in a group of lymphatic filariasis patients and healthy controls. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0), the Dermatology Life Quality Index (DLQI), and the Lymphatic Filariasis Quality of Life Questionnaire (LFSQQ) were administered to 36 stage II and stage III lymphatic filariasis subjects and 36 age and sex matched controls in Kerala, India. All three tools yielded missing value rates lower than 10%, suggesting high feasibility. Highest internal consistency was seen in the LFSQQ (α = 0.97). Discriminant validity analysis demonstrated that HRQoL was significantly lower in the LF group than in controls for the WHODAS 2.0, DLQI, and LFSQQ, but total HRQoL scores did not differ between stage II and stage III lymphedema subjects. The LFSQQ total score correlated most strongly with the WHODAS 2.0 (r = 0.91, p
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0002716