The association of transporter genes polymorphisms and lung cancer chemotherapy response

Lung cancer is one of the most common cancers and is the leading cause of death worldwide. Platinum-based chemotherapy is the main treatment method in lung cancer patients. Our previous studies indicated that single nucleotide polymorphisms (SNPs) in some transporter genes played important role in p...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2014-03, Vol.9 (3), p.e91967-e91967
Main Authors: Wang, Ying, Yin, Ji-Ye, Li, Xiang-Ping, Chen, Juan, Qian, Chen-Yue, Zheng, Yi, Fu, Yi-Lan, Chen, Zi-Yu, Zhou, Hong-Hao, Liu, Zhao-Qian
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Antineoplastic agents
Antineoplastic Agents - therapeutic use
Aquaporin 2
Aquaporin 2 - genetics
Aquaporins
Aquaporins - genetics
Biology and Life Sciences
Cancer
Cancer genetics
Cancer therapies
Carboplatin - therapeutic use
Carcinoma, Non-Small-Cell Lung - drug therapy
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - pathology
Care and treatment
Chemotherapy
Cisplatin - therapeutic use
Drug Resistance, Neoplasm - genetics
Female
Genes
Genetic aspects
Histology
Humans
Laboratories
Leukemia
Lung cancer
Lung diseases
Lung Neoplasms - drug therapy
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Medical research
Medicine and Health Sciences
Membrane Proteins - genetics
Middle Aged
Models, Genetic
Mutation
Oct-2 protein
Oncology
Organic Cation Transport Proteins - genetics
Organic Cation Transporter 2
Patients
Pharmacology
Physical Sciences
Platinum
Polymorphism, Single Nucleotide
Proteins
Research and Analysis Methods
Response Evaluation Criteria in Solid Tumors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Small Cell Lung Carcinoma - drug therapy
Small Cell Lung Carcinoma - genetics
Small Cell Lung Carcinoma - pathology
Smoking
Studies
Treatment Outcome
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c692t-9261f1f59978b2eb65ee9e8c64de45de013ba8ce525daee7ce8f9385828e630d3
cites cdi_FETCH-LOGICAL-c692t-9261f1f59978b2eb65ee9e8c64de45de013ba8ce525daee7ce8f9385828e630d3
container_end_page e91967
container_issue 3
container_start_page e91967
container_title PloS one
container_volume 9
creator Wang, Ying
Yin, Ji-Ye
Li, Xiang-Ping
Chen, Juan
Qian, Chen-Yue
Zheng, Yi
Fu, Yi-Lan
Chen, Zi-Yu
Zhou, Hong-Hao
Liu, Zhao-Qian
description Lung cancer is one of the most common cancers and is the leading cause of death worldwide. Platinum-based chemotherapy is the main treatment method in lung cancer patients. Our previous studies indicated that single nucleotide polymorphisms (SNPs) in some transporter genes played important role in platinum-based chemotherapy efficacy. The aim of this study was to investigate the association of SNPs in transporter genes and platinum-based chemotherapy efficacy. The main polymorphisms on transporters OCT2, LRP, AQP2, AQP9 and TMEM205 genes were genotyped in 338 lung cancer patients. The rs195854 in genotypic model, rs896412 in genotypic and recessive models for all subjects showed significant association with chemotherapy response. In stratification analysis, TMEM205 rs896412, OCT2 rs1869641 and rs195854, AQP9 rs1516400 and AQP2 rs7314734 showed significant relation to chemotherapy response. In conclusion, the genetic polymorphisms in OCT2, AQP2, AQP9 and TMEM205 may contribute to chemotherapy response in lung cancer patients.
doi_str_mv 10.1371/journal.pone.0091967
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1508464095</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478758988</galeid><doaj_id>oai_doaj_org_article_ca03f0fe10a94f998afb1b0eaa7a977f</doaj_id><sourcerecordid>A478758988</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-9261f1f59978b2eb65ee9e8c64de45de013ba8ce525daee7ce8f9385828e630d3</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7rr6D0QLgujFjEnTtMmNsCx-DCws6CrehdP0ZNqlTWrSivPvzTjdZSp7IblISJ73Tc7JOUnynJI1ZSV9d-Mmb6FbD87imhBJZVE-SE6pZNmqyAh7eLQ-SZ6EcEMIZ6IoHicnWV7kLCP5afLjusEUQnC6hbF1NnUmHT3YMDg_ok-3aDGkg-t2vfND04Y-pGDrtJvsNtVgdWR0g70bG_Qw7FKPUWoDPk0eGegCPpvns-Tbxw_XF59Xl1efNhfnlytdyGxcyayghhouZSmqDKuCI0oUushrzHmNhLIKhEae8RoQS43CSCa4yAQWjNTsLHl58B06F9SclKAoJyIGSSSPxOZA1A5u1ODbHvxOOWjV3w3ntwr82OoOlQbCDDFICcjcSCnAVLQiCFCCLEsTvd7Pt01Vj7VGG5PVLUyXJ7Zt1Nb9UkxykZM8GryZDbz7OWEYVd8GjV0HFt10eLfMecGKiL76B70_upnaQgygtcbFe_XeVJ3npSi5kEJEan0PFUeNfatjBZk27i8EbxeCyIz4e9zCFILafP3y_-zV9yX7-ohtELqxCa6b9rUXlmB-ALV3IXg0d0mmRO0b4DYbat8Aam6AKHtx_EF3otuKZ38AyVgC6w</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1508464095</pqid></control><display><type>article</type><title>The association of transporter genes polymorphisms and lung cancer chemotherapy response</title><source>Open Access: PubMed Central</source><source>Publicly Available Content Database</source><creator>Wang, Ying ; Yin, Ji-Ye ; Li, Xiang-Ping ; Chen, Juan ; Qian, Chen-Yue ; Zheng, Yi ; Fu, Yi-Lan ; Chen, Zi-Yu ; Zhou, Hong-Hao ; Liu, Zhao-Qian</creator><contributor>Katoh, Masaru</contributor><creatorcontrib>Wang, Ying ; Yin, Ji-Ye ; Li, Xiang-Ping ; Chen, Juan ; Qian, Chen-Yue ; Zheng, Yi ; Fu, Yi-Lan ; Chen, Zi-Yu ; Zhou, Hong-Hao ; Liu, Zhao-Qian ; Katoh, Masaru</creatorcontrib><description>Lung cancer is one of the most common cancers and is the leading cause of death worldwide. Platinum-based chemotherapy is the main treatment method in lung cancer patients. Our previous studies indicated that single nucleotide polymorphisms (SNPs) in some transporter genes played important role in platinum-based chemotherapy efficacy. The aim of this study was to investigate the association of SNPs in transporter genes and platinum-based chemotherapy efficacy. The main polymorphisms on transporters OCT2, LRP, AQP2, AQP9 and TMEM205 genes were genotyped in 338 lung cancer patients. The rs195854 in genotypic model, rs896412 in genotypic and recessive models for all subjects showed significant association with chemotherapy response. In stratification analysis, TMEM205 rs896412, OCT2 rs1869641 and rs195854, AQP9 rs1516400 and AQP2 rs7314734 showed significant relation to chemotherapy response. In conclusion, the genetic polymorphisms in OCT2, AQP2, AQP9 and TMEM205 may contribute to chemotherapy response in lung cancer patients.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0091967</identifier><identifier>PMID: 24643204</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Analysis ; Antineoplastic agents ; Antineoplastic Agents - therapeutic use ; Aquaporin 2 ; Aquaporin 2 - genetics ; Aquaporins ; Aquaporins - genetics ; Biology and Life Sciences ; Cancer ; Cancer genetics ; Cancer therapies ; Carboplatin - therapeutic use ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - pathology ; Care and treatment ; Chemotherapy ; Cisplatin - therapeutic use ; Drug Resistance, Neoplasm - genetics ; Female ; Genes ; Genetic aspects ; Histology ; Humans ; Laboratories ; Leukemia ; Lung cancer ; Lung diseases ; Lung Neoplasms - drug therapy ; Lung Neoplasms - genetics ; Lung Neoplasms - pathology ; Male ; Medical research ; Medicine and Health Sciences ; Membrane Proteins - genetics ; Middle Aged ; Models, Genetic ; Mutation ; Oct-2 protein ; Oncology ; Organic Cation Transport Proteins - genetics ; Organic Cation Transporter 2 ; Patients ; Pharmacology ; Physical Sciences ; Platinum ; Polymorphism, Single Nucleotide ; Proteins ; Research and Analysis Methods ; Response Evaluation Criteria in Solid Tumors ; Single nucleotide polymorphisms ; Single-nucleotide polymorphism ; Small Cell Lung Carcinoma - drug therapy ; Small Cell Lung Carcinoma - genetics ; Small Cell Lung Carcinoma - pathology ; Smoking ; Studies ; Treatment Outcome ; Tumors</subject><ispartof>PloS one, 2014-03, Vol.9 (3), p.e91967-e91967</ispartof><rights>COPYRIGHT 2014 Public Library of Science</rights><rights>2014 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2014 Wang et al 2014 Wang et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-9261f1f59978b2eb65ee9e8c64de45de013ba8ce525daee7ce8f9385828e630d3</citedby><cites>FETCH-LOGICAL-c692t-9261f1f59978b2eb65ee9e8c64de45de013ba8ce525daee7ce8f9385828e630d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1508464095/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1508464095?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24643204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Katoh, Masaru</contributor><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Yin, Ji-Ye</creatorcontrib><creatorcontrib>Li, Xiang-Ping</creatorcontrib><creatorcontrib>Chen, Juan</creatorcontrib><creatorcontrib>Qian, Chen-Yue</creatorcontrib><creatorcontrib>Zheng, Yi</creatorcontrib><creatorcontrib>Fu, Yi-Lan</creatorcontrib><creatorcontrib>Chen, Zi-Yu</creatorcontrib><creatorcontrib>Zhou, Hong-Hao</creatorcontrib><creatorcontrib>Liu, Zhao-Qian</creatorcontrib><title>The association of transporter genes polymorphisms and lung cancer chemotherapy response</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Lung cancer is one of the most common cancers and is the leading cause of death worldwide. Platinum-based chemotherapy is the main treatment method in lung cancer patients. Our previous studies indicated that single nucleotide polymorphisms (SNPs) in some transporter genes played important role in platinum-based chemotherapy efficacy. The aim of this study was to investigate the association of SNPs in transporter genes and platinum-based chemotherapy efficacy. The main polymorphisms on transporters OCT2, LRP, AQP2, AQP9 and TMEM205 genes were genotyped in 338 lung cancer patients. The rs195854 in genotypic model, rs896412 in genotypic and recessive models for all subjects showed significant association with chemotherapy response. In stratification analysis, TMEM205 rs896412, OCT2 rs1869641 and rs195854, AQP9 rs1516400 and AQP2 rs7314734 showed significant relation to chemotherapy response. In conclusion, the genetic polymorphisms in OCT2, AQP2, AQP9 and TMEM205 may contribute to chemotherapy response in lung cancer patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Aquaporin 2</subject><subject>Aquaporin 2 - genetics</subject><subject>Aquaporins</subject><subject>Aquaporins - genetics</subject><subject>Biology and Life Sciences</subject><subject>Cancer</subject><subject>Cancer genetics</subject><subject>Cancer therapies</subject><subject>Carboplatin - therapeutic use</subject><subject>Carcinoma, Non-Small-Cell Lung - drug therapy</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Cisplatin - therapeutic use</subject><subject>Drug Resistance, Neoplasm - genetics</subject><subject>Female</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Histology</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Leukemia</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Membrane Proteins - genetics</subject><subject>Middle Aged</subject><subject>Models, Genetic</subject><subject>Mutation</subject><subject>Oct-2 protein</subject><subject>Oncology</subject><subject>Organic Cation Transport Proteins - genetics</subject><subject>Organic Cation Transporter 2</subject><subject>Patients</subject><subject>Pharmacology</subject><subject>Physical Sciences</subject><subject>Platinum</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proteins</subject><subject>Research and Analysis Methods</subject><subject>Response Evaluation Criteria in Solid Tumors</subject><subject>Single nucleotide polymorphisms</subject><subject>Single-nucleotide polymorphism</subject><subject>Small Cell Lung Carcinoma - drug therapy</subject><subject>Small Cell Lung Carcinoma - genetics</subject><subject>Small Cell Lung Carcinoma - pathology</subject><subject>Smoking</subject><subject>Studies</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLgujFjEnTtMmNsCx-DCws6CrehdP0ZNqlTWrSivPvzTjdZSp7IblISJ73Tc7JOUnynJI1ZSV9d-Mmb6FbD87imhBJZVE-SE6pZNmqyAh7eLQ-SZ6EcEMIZ6IoHicnWV7kLCP5afLjusEUQnC6hbF1NnUmHT3YMDg_ok-3aDGkg-t2vfND04Y-pGDrtJvsNtVgdWR0g70bG_Qw7FKPUWoDPk0eGegCPpvns-Tbxw_XF59Xl1efNhfnlytdyGxcyayghhouZSmqDKuCI0oUushrzHmNhLIKhEae8RoQS43CSCa4yAQWjNTsLHl58B06F9SclKAoJyIGSSSPxOZA1A5u1ODbHvxOOWjV3w3ntwr82OoOlQbCDDFICcjcSCnAVLQiCFCCLEsTvd7Pt01Vj7VGG5PVLUyXJ7Zt1Nb9UkxykZM8GryZDbz7OWEYVd8GjV0HFt10eLfMecGKiL76B70_upnaQgygtcbFe_XeVJ3npSi5kEJEan0PFUeNfatjBZk27i8EbxeCyIz4e9zCFILafP3y_-zV9yX7-ohtELqxCa6b9rUXlmB-ALV3IXg0d0mmRO0b4DYbat8Aam6AKHtx_EF3otuKZ38AyVgC6w</recordid><startdate>20140318</startdate><enddate>20140318</enddate><creator>Wang, Ying</creator><creator>Yin, Ji-Ye</creator><creator>Li, Xiang-Ping</creator><creator>Chen, Juan</creator><creator>Qian, Chen-Yue</creator><creator>Zheng, Yi</creator><creator>Fu, Yi-Lan</creator><creator>Chen, Zi-Yu</creator><creator>Zhou, Hong-Hao</creator><creator>Liu, Zhao-Qian</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20140318</creationdate><title>The association of transporter genes polymorphisms and lung cancer chemotherapy response</title><author>Wang, Ying ; Yin, Ji-Ye ; Li, Xiang-Ping ; Chen, Juan ; Qian, Chen-Yue ; Zheng, Yi ; Fu, Yi-Lan ; Chen, Zi-Yu ; Zhou, Hong-Hao ; Liu, Zhao-Qian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-9261f1f59978b2eb65ee9e8c64de45de013ba8ce525daee7ce8f9385828e630d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Aquaporin 2</topic><topic>Aquaporin 2 - genetics</topic><topic>Aquaporins</topic><topic>Aquaporins - genetics</topic><topic>Biology and Life Sciences</topic><topic>Cancer</topic><topic>Cancer genetics</topic><topic>Cancer therapies</topic><topic>Carboplatin - therapeutic use</topic><topic>Carcinoma, Non-Small-Cell Lung - drug therapy</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Cisplatin - therapeutic use</topic><topic>Drug Resistance, Neoplasm - genetics</topic><topic>Female</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Histology</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Leukemia</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine and Health Sciences</topic><topic>Membrane Proteins - genetics</topic><topic>Middle Aged</topic><topic>Models, Genetic</topic><topic>Mutation</topic><topic>Oct-2 protein</topic><topic>Oncology</topic><topic>Organic Cation Transport Proteins - genetics</topic><topic>Organic Cation Transporter 2</topic><topic>Patients</topic><topic>Pharmacology</topic><topic>Physical Sciences</topic><topic>Platinum</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proteins</topic><topic>Research and Analysis Methods</topic><topic>Response Evaluation Criteria in Solid Tumors</topic><topic>Single nucleotide polymorphisms</topic><topic>Single-nucleotide polymorphism</topic><topic>Small Cell Lung Carcinoma - drug therapy</topic><topic>Small Cell Lung Carcinoma - genetics</topic><topic>Small Cell Lung Carcinoma - pathology</topic><topic>Smoking</topic><topic>Studies</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Yin, Ji-Ye</creatorcontrib><creatorcontrib>Li, Xiang-Ping</creatorcontrib><creatorcontrib>Chen, Juan</creatorcontrib><creatorcontrib>Qian, Chen-Yue</creatorcontrib><creatorcontrib>Zheng, Yi</creatorcontrib><creatorcontrib>Fu, Yi-Lan</creatorcontrib><creatorcontrib>Chen, Zi-Yu</creatorcontrib><creatorcontrib>Zhou, Hong-Hao</creatorcontrib><creatorcontrib>Liu, Zhao-Qian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints In Context</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Databases</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Ying</au><au>Yin, Ji-Ye</au><au>Li, Xiang-Ping</au><au>Chen, Juan</au><au>Qian, Chen-Yue</au><au>Zheng, Yi</au><au>Fu, Yi-Lan</au><au>Chen, Zi-Yu</au><au>Zhou, Hong-Hao</au><au>Liu, Zhao-Qian</au><au>Katoh, Masaru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of transporter genes polymorphisms and lung cancer chemotherapy response</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2014-03-18</date><risdate>2014</risdate><volume>9</volume><issue>3</issue><spage>e91967</spage><epage>e91967</epage><pages>e91967-e91967</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Lung cancer is one of the most common cancers and is the leading cause of death worldwide. Platinum-based chemotherapy is the main treatment method in lung cancer patients. Our previous studies indicated that single nucleotide polymorphisms (SNPs) in some transporter genes played important role in platinum-based chemotherapy efficacy. The aim of this study was to investigate the association of SNPs in transporter genes and platinum-based chemotherapy efficacy. The main polymorphisms on transporters OCT2, LRP, AQP2, AQP9 and TMEM205 genes were genotyped in 338 lung cancer patients. The rs195854 in genotypic model, rs896412 in genotypic and recessive models for all subjects showed significant association with chemotherapy response. In stratification analysis, TMEM205 rs896412, OCT2 rs1869641 and rs195854, AQP9 rs1516400 and AQP2 rs7314734 showed significant relation to chemotherapy response. In conclusion, the genetic polymorphisms in OCT2, AQP2, AQP9 and TMEM205 may contribute to chemotherapy response in lung cancer patients.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>24643204</pmid><doi>10.1371/journal.pone.0091967</doi><tpages>e91967</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2014-03, Vol.9 (3), p.e91967-e91967
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1508464095
source Open Access: PubMed Central; Publicly Available Content Database
subjects Adult
Aged
Analysis
Antineoplastic agents
Antineoplastic Agents - therapeutic use
Aquaporin 2
Aquaporin 2 - genetics
Aquaporins
Aquaporins - genetics
Biology and Life Sciences
Cancer
Cancer genetics
Cancer therapies
Carboplatin - therapeutic use
Carcinoma, Non-Small-Cell Lung - drug therapy
Carcinoma, Non-Small-Cell Lung - genetics
Carcinoma, Non-Small-Cell Lung - pathology
Care and treatment
Chemotherapy
Cisplatin - therapeutic use
Drug Resistance, Neoplasm - genetics
Female
Genes
Genetic aspects
Histology
Humans
Laboratories
Leukemia
Lung cancer
Lung diseases
Lung Neoplasms - drug therapy
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Male
Medical research
Medicine and Health Sciences
Membrane Proteins - genetics
Middle Aged
Models, Genetic
Mutation
Oct-2 protein
Oncology
Organic Cation Transport Proteins - genetics
Organic Cation Transporter 2
Patients
Pharmacology
Physical Sciences
Platinum
Polymorphism, Single Nucleotide
Proteins
Research and Analysis Methods
Response Evaluation Criteria in Solid Tumors
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Small Cell Lung Carcinoma - drug therapy
Small Cell Lung Carcinoma - genetics
Small Cell Lung Carcinoma - pathology
Smoking
Studies
Treatment Outcome
Tumors
title The association of transporter genes polymorphisms and lung cancer chemotherapy response
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T23%3A10%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20association%20of%20transporter%20genes%20polymorphisms%20and%20lung%20cancer%20chemotherapy%20response&rft.jtitle=PloS%20one&rft.au=Wang,%20Ying&rft.date=2014-03-18&rft.volume=9&rft.issue=3&rft.spage=e91967&rft.epage=e91967&rft.pages=e91967-e91967&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0091967&rft_dat=%3Cgale_plos_%3EA478758988%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c692t-9261f1f59978b2eb65ee9e8c64de45de013ba8ce525daee7ce8f9385828e630d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1508464095&rft_id=info:pmid/24643204&rft_galeid=A478758988&rfr_iscdi=true