Enhanced adult neurogenesis increases brain stiffness: in vivo magnetic resonance elastography in a mouse model of dopamine depletion

• Published in: PloS one 2014-03, Vol.9 (3), p.e92582
• Main Authors: Klein, Charlotte, Hain, Elisabeth G, Braun, Juergen, Riek, Kerstin, Mueller, Susanne, Steiner, Barbara, Sack, Ingolf
• Format: Article
• Language: English
• Subjects: Aging; Animals; Biology and Life Sciences; Brain; Brain - metabolism; Brain - pathology; Dentate gyrus; Diagnostic systems; Disease; Disease Models, Animal; Dopamine; Dopamine - deficiency; Dopamine receptors; Elasticity; Elasticity Imaging Techniques; Female; Hippocampal plasticity; Hippocampus; Magnetic resonance; Mechanical analysis; Medical imaging; Medicine; Medicine and Health Sciences; Mice; Mice, Transgenic; Microscopy; Movement disorders; MPTP; MPTP Poisoning - metabolism; MPTP Poisoning - pathology; Neurodegeneration; Neurodegenerative diseases; Neurogenesis; Neuroimaging; Neurology; Neuronal Plasticity; Neurons; Neurons - metabolism; Neurons - pathology; Neuroplasticity; Neurosciences; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Phenols (Class of compounds); Physical Sciences; Physiology; Plasticity (neural); Research and Analysis Methods; Resonance; Rodents; Stiffness; Stroke; Viscoelasticity
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0092582

The mechanical network of the brain is a major contributor to neural health and has been recognized by in vivo magnetic resonance elastography (MRE) to be highly responsive to diseases. However, until now only brain softening was observed and no mechanism was known that reverses the common decrement of neural elasticity during aging or disease. We used MRE in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) mouse model for dopaminergic neurodegeneration as observed in Parkinson's disease (PD) to study the mechanical response of the brain on adult hippocampal neurogenesis as a robust correlate of neuronal plasticity in healthy and injured brain. We observed a steep transient rise in elasticity within the hippocampal region of up to over 50% six days after MPTP treatment correlating with increased neuronal density in the dentate gyrus, which could not be detected in healthy controls. Our results provide the first indication that new neurons reactively generated following neurodegeneration substantially contribute to the mechanical scaffold of the brain. Diagnostic neuroimaging may thus target on regions of the brain displaying symptomatically elevated elasticity values for the detection of neuronal plasticity following neurodegeneration.