Studying the system-level involvement of microRNAs in Parkinson's disease

Parkinson's Disease (PD) is a progressive neurologic disorder that affects movement and balance. Recent studies have revealed the importance of microRNA (miR) in PD. However, the detailed role of miR and its regulation by Transcription Factor (TF) remain unexplored. In this work for the first t...

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Bibliographic Details
Published in:PloS one 2014-04, Vol.9 (4), p.e93751-e93751
Main Authors: Chatterjee, Paulami, Bhattacharyya, Malay, Bandyopadhyay, Sanghamitra, Roy, Debjani
Format: Article
Language:English
Subjects:
Alzheimer's disease
Alzheimers disease
Analysis
Bioindicators
Biological activity
Biology and life sciences
Biomarkers
Biophysics
Cardiovascular disease
Care and treatment
Cluster Analysis
Clustering
Comparative analysis
Computer and Information Sciences
Conservation
Crosstalk
Development and progression
Diagnosis
DNA microarrays
Dopamine
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Gene regulation
Gene Regulatory Networks
Genomes
Humans
Medicine and Health Sciences
MicroRNA
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Mitogen-Activated Protein Kinase Kinases - genetics
Mitogen-Activated Protein Kinase Kinases - metabolism
Movement disorders
Neurodegenerative diseases
Ovarian cancer
Parkinson Disease - genetics
Parkinson Disease - pathology
Parkinson's disease
Parkinsons disease
Pathways
Principal components analysis
Research and Analysis Methods
Ribonucleic acid
Risk factors
RNA
RNA, Messenger
Transcription, Genetic
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Description
Summary:Parkinson's Disease (PD) is a progressive neurologic disorder that affects movement and balance. Recent studies have revealed the importance of microRNA (miR) in PD. However, the detailed role of miR and its regulation by Transcription Factor (TF) remain unexplored. In this work for the first time we have studied TF-miR-mRNA regulatory network as well as miR co-expression network in PD. We compared the 204 differentially expressed miRs from microarray data with 73 PD related miRs obtained from literature, Human MicroRNA Disease Database and found a significant overlap of 47 PD related miRs (p-value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0093751