Quantitative assessment of the effect of KCNJ11 gene polymorphism on the risk of type 2 diabetes

• Published in: PloS one 2014-04, Vol.9 (4), p.e93961-e93961
• Main Authors: Qiu, Ling, Na, Risu, Xu, Rong, Wang, Siyang, Sheng, Hongguang, Wu, Wanling, Qu, Yi
• Format: Article
• Language: English
• Subjects: Adenosine triphosphate; Alleles; Analysis; Asian Continental Ancestry Group - genetics; Biology and Life Sciences; Body mass; Body mass index; Care and treatment; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - genetics; Diagnosis; Endocrinology; Epidemics; Ethnicity; European Continental Ancestry Group - genetics; Gene polymorphism; Genes; Genetic aspects; Genetic Association Studies; Genetic diversity; Genetic polymorphisms; Genetic Predisposition to Disease; Genetic variance; Genotype; Geriatrics; Health risks; Humans; Insulin resistance; KCNJ11 gene; Medicine and Health Sciences; Meta-analysis; Minority & ethnic groups; Pancreatic beta cells; Physical Sciences; Polymorphism; Polymorphism, Single Nucleotide; Population; Populations; Potassium; Potassium Channels, Inwardly Rectifying - genetics; Regression analysis; Research and Analysis Methods; Risk factors; Statistical analysis; Studies; Type 2 diabetes
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0093961

To clarify the role of potassium inwardly-rectifying-channel, subfamily-J, member 11 (KCNJ11) variation in susceptibility to type 2 diabetes (T2D), we performed a systematic meta-analysis to investigate the association between the KCNJ11 E23K polymorphism (rs5219) and the T2D in different genetic models. Databases including PubMed, Medline, EMBASE, and ISI Web of Science were searched to identify relevant studies. A total of 48 published studies involving 56,349 T2D cases, 81,800 controls, and 483 family trios were included in this meta-analysis. Overall, the E23K polymorphism was significantly associated with increased T2D risk with per-allele odds ratio (OR) of 1.12 (95% CI: 1.09-1.16; P