Cardio-respiratory coordination increases during sleep apnea

Cardiovascular diseases are the main source of morbidity and mortality in the United States with costs of more than $170 billion. Repetitive respiratory disorders during sleep are assumed to be a major cause of these diseases. Therefore, the understanding of the cardio-respiratory regulation during...

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Bibliographic Details
Published in:PloS one 2014-04, Vol.9 (4), p.e93866-e93866
Main Authors: Riedl, Maik, Müller, Andreas, Kraemer, Jan F, Penzel, Thomas, Kurths, Juergen, Wessel, Niels
Format: Article
Language:English
Subjects:
Adult
Apnea
Autonomic Nervous System - physiopathology
Biology and Life Sciences
Cardiology
Cardiovascular diseases
Cardiovascular Diseases - etiology
Complications and side effects
Computer and Information Sciences
Contingency tables
Disturbances
Engineering and Technology
Heart diseases
Heart rate
Heart Rate - physiology
Humans
Male
Males
Medicine and Health Sciences
Models, Cardiovascular
Morbidity
Oscillations
Patient outcomes
Phase transitions
Physical Sciences
Physics
Public concern
Respiration
Respiratory Rate - physiology
Risk factors
Sinuses
Sleep
Sleep apnea
Sleep apnea syndromes
Sleep Apnea Syndromes - complications
Sleep Apnea Syndromes - physiopathology
Sleep Apnea, Obstructive - physiopathology
Sleep disorders
Sleep Stages - physiology
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Summary:Cardiovascular diseases are the main source of morbidity and mortality in the United States with costs of more than $170 billion. Repetitive respiratory disorders during sleep are assumed to be a major cause of these diseases. Therefore, the understanding of the cardio-respiratory regulation during these events is of high public interest. One of the governing mechanisms is the mutual influence of the cardiac and respiratory oscillations on their respective onsets, the cardio-respiratory coordination (CRC). We analyze this mechanism based on nocturnal measurements of 27 males suffering from obstructive sleep apnea syndrome. Here we find, by using an advanced analysis technique, the cardiogram, not only that the occurrence of CRC is significantly more frequent during respiratory sleep disturbances than in normal respiration (p-value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0093866