An intra-individual comparison of MRI, [18F]-FET and [18F]-FLT PET in patients with high-grade gliomas

Intra-individual spatial overlap analysis of tumor volumes assessed by MRI, the amino acid PET tracer [18F]-FET and the nucleoside PET tracer [18F]-FLT in high-grade gliomas (HGG). MRI, [18F]-FET and [18F]-FLT PET data sets were retrospectively analyzed in 23 HGG patients. Morphologic tumor volumes...

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Bibliographic Details
Published in:PloS one 2014-04, Vol.9 (4), p.e95830-e95830
Main Authors: Nowosielski, Martha, DiFranco, Matthew D, Putzer, Daniel, Seiz, Marcel, Recheis, Wolfgang, Jacobs, Andreas H, Stockhammer, Günther, Hutterer, Markus
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Amino acids
Biology and Life Sciences
Blood-brain barrier
Brain cancer
Chemotherapy
Correlation
Correlation coefficient
Correlation coefficients
Data processing
Female
Fluorodeoxyglucose F18
Glioma
Glioma - diagnosis
Humans
Image contrast
Image processing
Image segmentation
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical diagnosis
Medical imaging
Medicine and Health Sciences
Metabolism
Middle Aged
Neurology
Neurosurgery
NMR
Nuclear magnetic resonance
Patients
Pets
Positron emission
Positron emission tomography
Positron-Emission Tomography - methods
Radiation therapy
Segmentation
Spatial analysis
Studies
Tomography
Tumors
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Summary:Intra-individual spatial overlap analysis of tumor volumes assessed by MRI, the amino acid PET tracer [18F]-FET and the nucleoside PET tracer [18F]-FLT in high-grade gliomas (HGG). MRI, [18F]-FET and [18F]-FLT PET data sets were retrospectively analyzed in 23 HGG patients. Morphologic tumor volumes on MRI (post-contrast T1 (cT1) and T2 images) were calculated using a semi-automatic image segmentation method. Metabolic tumor volumes for [18F]-FET and [18F]-FLT PETs were determined by image segmentation using a threshold-based volume of interest analysis. After co-registration with MRI the morphologic and metabolic tumor volumes were compared on an intra-individual basis in order to estimate spatial overlaps using the Spearman's rank correlation coefficient and the Mann-Whitney U test. [18F]-FLT uptake was negative in tumors with no or only moderate contrast enhancement on MRI, detecting only 21 of 23 (91%) HGG. In addition, [18F]-FLT uptake was mainly restricted to cT1 tumor areas on MRI and [18F]-FLT volumes strongly correlated with cT1 volumes (r = 0.841, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0095830