Dorsal striatal dopamine, food preference and health perception in humans

To date, few studies have explored the neurochemical mechanisms supporting individual differences in food preference in humans. Here we investigate how dorsal striatal dopamine, as measured by the positron emission tomography (PET) tracer [(18)F]fluorometatyrosine (FMT), correlates with food-related...

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Bibliographic Details
Published in:PloS one 2014-05, Vol.9 (5), p.e96319-e96319
Main Authors: Wallace, Deanna L, Aarts, Esther, Dang, Linh C, Greer, Stephanie M, Jagust, William J, D'Esposito, Mark
Format: Article
Language:English
Subjects:
Adult
Biology and Life Sciences
Body mass
Body mass index
Body size
Corpus Striatum - metabolism
Decision making
Diet
Dopamine
Dopamine - metabolism
Eating disorders
Emission analysis
Emission measurements
Female
Food
Food preferences
Food Preferences - physiology
Humans
Hydrocarbons, Fluorinated
Laboratories
Ligands
Male
Medical imaging
Medicine and Health Sciences
Neostriatum
Neurophysiology
Neurosciences
Obesity
Parkinson's disease
Perception - physiology
Perceptions
Phenols (Class of compounds)
Positron emission
Positron emission tomography
Preferences
Studies
Tomography
Young Adult
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Summary:To date, few studies have explored the neurochemical mechanisms supporting individual differences in food preference in humans. Here we investigate how dorsal striatal dopamine, as measured by the positron emission tomography (PET) tracer [(18)F]fluorometatyrosine (FMT), correlates with food-related decision-making, as well as body mass index (BMI) in 16 healthy-weight to moderately obese individuals. We find that lower PET FMT dopamine synthesis binding potential correlates with higher BMI, greater preference for perceived "healthy" foods, but also greater healthiness ratings for food items. These findings further substantiate the role of dorsal striatal dopamine in food-related behaviors and shed light on the complexity of individual differences in food preference.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0096319